Dr Helder Ferreira


BMS B303
tel. 01334 463425
fax. 01334 462495

My research focusses on chromatin structure and dynamics. In particular, I am interested in ATP-dependent chromatin remodeling enzymes and telomere maintenance. My aim is to combine chemical genetics with in vitro biochemistry to obtain mechanistic insight into novel chromatin remodeling enzymes and the means by which they affect telomere function. 



Sundaramoorthy, R, Hughes, AL, El-Mkami, H, Norman, DG, Ferreira, H & Owen-Hughes, T 2018, 'Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome' eLife, vol. 7, e35720. DOI: 10.7554/eLife.35720
Swanston, A, Zabrady, K & Ferreira, HC 2018, 'The ATP-dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning' biorxiv. DOI: 10.1101/412783
Ferreira, HC, Towbin, BD, Jegou, T & Gasser, SM 2013, 'The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery' Journal of Cell Biology, vol. 203, no. 5, pp. 727-735. DOI: 10.1083/jcb.201307181
Kueng, S, Tsai-Pflugfelder, M, Oppikofer, M, Ferreira, HC, Roberts, E, Tsai, C, Roloff, T-C, Sack, R & Gasser, SM 2012, 'Regulating repression: roles for the Sir4 N-terminus in linker DNA protection and stabilization of epigenetic states' PLoS Genetics, vol. 8, no. 5, e1002727. DOI: 10.1371/journal.pgen.1002727
Ferreira, HC, Luke, B, Schober, H, Kalck, V, Lingner, J & Gasser, SM 2011, 'The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast' Nature Cell Biology, vol. 13, no. 7, pp. 867-874. DOI: 10.1038/ncb2263
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Dr Helder Ferreira
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST

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