University of St Andrews
 
 

Dr Judith Sleeman
Lecturer in Cell and Developmental Biology

Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
Fife
KY16 9ST
UK

Almost all mammalian genes contain introns, which are sequences represented in the DNA but not in the protein. These must be removed, or ‘spliced’, from the mRNA message before it can be translated. Accurate mRNA splicing requires a protein called Survival of Motor Neurons (SMN). Insufficient expression of SMN is responsible for the inherited neurodegenerative disease, spinal muscular atrophy (SMA). It is not clear how the loss of SMN protein leads to the disease. All cells need to splice their RNA correctly, but SMA specifically affects motor neurons. I'm studying the maturation of splicing factors, with a particular emphasis on their dynamics within the nucleus and differences between neural and non-neural cell types that may be significant for SMA

 

Publications

Sleeman, JE 2014, ' Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1. ' Biochemical Journal , vol 458, no. 2, pp. 267-280.
Sleeman, JE 2014, ' Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking. ' Journal of Cell Science , vol 127, no. 4, pp. 812-827.
Sleeman, J 2013, ' Small nuclear RNAs and mRNAs: linking RNA processing and transport to spinal muscular atrophy ' Biochemical Society Transactions , vol 41, no. 4, pp. 871-875.
Clelland, AK , Bales, ABE & Sleeman, JE 2012, ' Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy ' Journal of Cell Science , vol 125, no. 11, pp. 2626-2637.
Clelland, AK , Kinnear, NP , Oram, L, Burza, J & Sleeman, JE 2009, ' The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells ' Traffic , vol 10, no. 11, pp. 1585-1598.
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