University of St Andrews
 
 

this person is a member of the
School of Psychology and Neuroscience

Dr Wenchang Li
Royal Society University Research Fellow

Bute Building
University of St Andrews
St Andrews
Fife
KY16 9TS
UK

All animals are capable of producing stereotyped motor behavior to accommodate environmental changes or suit individual needs. Our research uses young Xenopus laevis tadpoles as a model system to study the basic neural mechanisms controlling animal movements, i.e. swimming. The tadpole spinal cord and hindbrain are simple and highly accessible, making it an ideal place to investigate rules that may be common to the movements of different animal species. Since the tadpoles are going through rapid development, I’m also interested in how neurons time their expression of ion channels, change their neurotransmission or connectivity to integrate with existing neural circuits. Research methods include electrophysiology, optogentics, pharmacology, anti-sense RNA, microinjection, computer modelling, anatomy and behavioural analyses.

Example projects

 

PhD opportunities: We always welcome inquiries from keen, motivated students. You should hold or expect to hold at least a 2nd upper BSc degree. Potential PhD projects can be largely in either motor control or developmental plasticity. For more details send your inquiries to wl21@st-andrews.ac.uk

 

Collaborators:

Dr Steve Soffe, Prof Alan Roberts in the University of Bristol.

Prof Roman Borisyuk in Plymouth University.

 

Current lab members

Dr Erik Svensson: Research fellow funded by BBSRC.

 

Previous Lab members:

Nicola Porter: PhD student funded by BBSRC.

Peter Moult: Research fellow funded by Wellcome Trust. Now a lecturer at Abertay University.

Hong-Yan Zhang: Short-term research fellow funded by Wellcome Trust. Now she has started her own lab in the University of Edinburgh.

 

 

Publications

Li, W , Merrison-Hort, R , Zhang, HY & Borisyuk, R 2014, ' The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator ' The Journal of Neuroscience , vol 34, no. 17, pp. 6065-77.
Li, W , Wagner, MA & Porter, NJ 2014, ' Behavioral observation of xenopus tadpole swimming for neuroscience labs ' Journal of Undergraduate Neuroscience Education , vol 12, no. 2, pp. A107-A113.
Moult, PR , Cottrell, GA & Li, W 2013, ' Fast silencing reveals a lost role for reciprocal inhibition in locomotion ' Neuron , vol 77, no. 1, pp. 129-140.
Li, W & Moult, PR 2012, ' The control of locomotor frequency by excitation and inhibition ' The Journal of Neuroscience , vol 32, no. 18, pp. 6220-6230.
Roberts, A , Li, W & Soffe, S 2012, ' A functional scaffold of CNS neurons for the vertebrates: The developing Xenopus laevis spinal cord (review) ' Developmental Neurobiology , vol 72, no. 4, pp. 575-584.
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