Nuclear Structure and Dynamics

Sleeman Lab
University of St Andrews , School of Biology

PhD Position Available

 

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RECENT:

"A role for CRM1 in multi-directional trafficking of splicing snRNPs in the mammalian nucleus." Sleeman, J.E. (2007) J. Cell Sci. 120:1540-15

“Molecular and functional characterisation of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family.” Kobayashi T., Sleeman, J.E., Coughtrie, M.W.H., Burchell, B. (2006) Biochem J. 400:281-9

"FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35." Chusainow J, Ajuh PM, Trinkle-Mulcahy L, Sleeman JE, Ellenberg J, Lamond AI. (2005) RNA Aug;11(8):1201-14.

"Dynamics of the mammalian nucleus: can microscopic movements help us to understand our genes?" Sleeman, JE. Phil Trans R Soc Lon A, 2004;362:1-19.

"Nuclear substructure and dynamics." Lamond AI and Sleeman JE. Curr. Biol.2003 October 28;13:R825-R828

“Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo.” Sleeman JE, Trinkle-Mulcahy L, Prescott AR, Ogg SC, Lamond AI. J Cell Sci. 2003 May 15;116:2039-50.ABSTRACT


“Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs.”Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT. J Cell Sci. 2003 May 15;116:1905-13.
ABSTRACT


“Time-lapse Imaging Reveals Dynamic Relocalization of PP1gamma throughout the Mammalian Cell Cycle.”Trinkle-Mulcahy L, Andrews PD, Wickramasinghe S, Sleeman J, Prescott A, Lam YW, Lyon C, Swedlow JR, Lamond AI. Mol Biol Cell. 2003 Jan;14(1):107-17.
ABSTRACT

LESS RECENT:


“snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN” Sleeman, J.E., Ajuh, P.M. and Lamond, A.I. (2001). J. Cell Sci. 114: 4407-4419.
ABSTRACT


“Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells” Trinkle-Mulcahy, L., Sleeman, J.E. and Lamond, A.I. (2001) J. Cell Sci.114: 4219-4228.
ABSTRACT


“A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing” Ajuh P., Sleeman J,E., Chusainow J., Lamond A.I. (2001) J Biol Chem. 276(45): 42370-81.
ABSTRACT


“Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway” Sleeman J.E., Lamond A.I. (1999) Curr Biol. 9(19): 1065-74.
ABSTRACT


“Nuclear organization of pre-mRNA splicing factors” Sleeman J.E., Lamond A.I.(1999)
Curr Opin Cell Biol.11 (3):372-7.
ABSTRACT


“Dynamic interactions between splicing snRNPs, coiled bodies and nucleoli revealed using snRNP protein fusions to the green fluorescent protein” Sleeman J., Lyon C.E., Platani M., Kreivi J.P., Lamond A.I. (1998) Exp Cell Res. 243(2): 290-304.


“Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex”
Neubauer G., King A., Rappsilber J., Calvio C., Watson M., Ajuh P., Sleeman J., Lamond A., Mann M. (1998) Nat Genet. 20(1): 46-50.


“Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus” Lyon C.E., Bohmann K., Sleeman J., Lamond AI. (1997) Exp Cell Res. 230(1): 84-93.


“Tumorigenicity associated with chromosome 11P15 alterations in SV40-transformed human kidney cells”
Poirier, V., Tyler, S.J., Sleeman, J., Diffin, F., Maitland, N.J., Brown, K.W. (1995). Int. J. Oncol.7 (3): 623-630.


Designed/maintained byJ.Sleeman
Last updated July 3rd 2007
These pages are the personal responsibility of Judith Sleeman. The views expressed here do not necessarily represent the official views of the University.