{"id":31889,"date":"2022-10-17T15:07:00","date_gmt":"2022-10-17T14:07:00","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/?p=31889"},"modified":"2023-05-24T11:31:30","modified_gmt":"2023-05-24T10:31:30","slug":"molecular-scale-optical-imaging-tools-for-decoding-the-structural-basis-of-cellular-signalling","status":"publish","type":"post","link":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/2022\/10\/17\/molecular-scale-optical-imaging-tools-for-decoding-the-structural-basis-of-cellular-signalling\/","title":{"rendered":"Molecular-scale optical imaging tools for decoding the structural basis of cellular signalling"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"194\" height=\"291\" src=\"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-content\/uploads\/sites\/13\/2022\/10\/Izzy.jpg\" alt=\"\" class=\"wp-image-31789\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p>Dr Izzy Jayasinghe, University of Sheffield<br>25 October 2022, 1.00pm, MS Teams<\/p>\n\n\n\n<p><a href=\"https:\/\/musclesuperres.wordpress.com\/about\/\">Applied Biophotonics Group<\/a><\/p>\n\n\n\n<p>In this seminar, I will outline how the continued improvement and strategic adaptation of super-resolution microscopy tools have enhanced our understanding of the nanoscale structures underpinning life. I will illustrate some of these advances with examples where super-resolution modalities such as STORM, DNA-PAINT and Expansion Microscopy have allowed us to better visualise ryanodine receptor (RyR) and IP3-receptor nanodomains in tissues like the heart, muscle and neural tissues. Correlative structure-function imaging has allowed us to resolve, count and identify the ion channel clustering patterns which spatially encode the fast calcium signals within the cells.\u00a0<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dr Izzy Jayasinghe, University of Sheffield25 October 2022, 1.00pm, MS Teams Applied Biophotonics Group In this seminar, I will outline how the continued improvement and strategic adaptation of super-resolution microscopy tools have enhanced our understanding of the nanoscale structures underpinning life. I will illustrate some of these advances with examples where super-resolution modalities such as&hellip;<\/p>\n","protected":false},"author":29,"featured_media":31790,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-full.php","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-31889","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-seminars"],"jetpack_featured_media_url":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-content\/uploads\/sites\/13\/2022\/10\/Izzy_lab-scaled-1.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/posts\/31889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/comments?post=31889"}],"version-history":[{"count":0,"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/posts\/31889\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/media\/31790"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/media?parent=31889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/categories?post=31889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/biophotonics\/wp-json\/wp\/v2\/tags?post=31889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}