Gunn-Moore
Group Highlights
My group has made major discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer’s disease (linking mitochondrial and synaptic dysfunction), where we have pioneered new models (including the first identification that cetaceans also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors (filed patents). Using both molecular and novel biophysical techniques, we have also discovered novel biochemical pathways that are involved in the growth and development of mammalian neurons. These findings include the first identification of the protein FRMD6/Willin as an upstream component of the Hippo pathway, which prior to our work, was thought to be involved only in cancer, but we have now linked its activity to Alzheimer’s disease progression.
I always claim that we are truly interdisciplinary, as we have published >140 papers in Biology, Chemistry and Physics journals, including a range of highly cited publications in top journals, e.g., Science, Nature Medicine, Nature Methods, Nature Protocols, Nature Communications and Science Advances and have been funded from highly competitive sources.
Research
- Inhibitors and activity of 17beta HSD10 in Alzheimer’s disease
- Willin/FRMD6 activity in Alzheimer’s disease
- Non-human models of dementia
- Biophotonics
Group Members
Publications
Chapters
Optical Transfection of Mammalian Cells
Antkowiak, M., Dholakia, K. & Gunn-Moore, F. J., 31 May 2015, Understanding Biophotonics - Fundamentals, Advances and Applications. Tsia, K. (ed.). p. 693-734
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Femtosecond optical injection of intact plant cells using a reconfigurable platform
Mitchell, C. A., Kalies, S., Cizmar, T., Bellini, N., Kubasik-Thayil, A., Heisterkamp, A., Torrance, L., Roberts, A. G., Gunn-Moore, F. J. & Dholakia, K., 1 Jan 2014, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 8972.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Imaging the cellular response to transient shear stress using time-resolved digital holography
Arita, Y., Antkowiak, M., Gunn-Moore, F. & Dholakia, K., 26 Feb 2014, Optical Elastography and Tissue Biomechanics. Larin, KV. & Sampson, DD. (eds.). Bellingham: SPIE, Vol. 8946. 7 p. (Proceedings of SPIE; vol. 8946).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Single cell transfection by laser-induced breakdown of an optically trapped gold nanoparticle
Arita, Y., Ploschner, M., Antkowiak, M., Gunn-Moore, F. & Dholakia, K., 7 Mar 2014, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIV. Heisterkamp, A., Herman, PR., Meunier, M. & Nolte, S. (eds.). Bellingham: SPIE, Vol. 8972. 7 p. (Proceedings of SPIE; vol. 8972).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Wavefront shaping of a Bessel light field enhances light sheet microscopy with scattered light
Nylk, J., Mitchell, C., Vettenburg, T., Gunn-Moore, F. J. & Dholakia, K., 12 Mar 2014, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI. Brown, TG., Cogswell, CJ. & Wilson, T. (eds.). Bellingham: SPIE, Vol. 8949. 8 p. (Proceedings of SPIE; vol. 8949).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Optical sculpting: trapping through disorder and transfer of orbital angular momentum
Cizmar, T., Mazilu, M., Dalgarno, H., Ashok, P., Gunn-Moore, F. & Dholakia, K., 3 Feb 2011, Complex Light and Optical Forces V. Andrews, D. L., Galvez, E. J. & Gluckstad, J. (eds.). SPIE, p. 79500R 7 p. (Proceedings of SPIE; vol. 7950).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Optical Sculpting: Shaping the Future of Biophotonics
Dholakia, K., Cizmar, T., Mazilu, M., Baumgartl, J., Tsampoula, X. & Gunn-Moore, F., 2010, Third International Workshop on Theoretical and Computational Nano-Photonics (TaCoNa-Photonics 2010) . Chigrin, D. N. (ed.). American Institute of Physics, p. 1-2 2 p. (AIP Conference Proceedings; vol. 1291).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Transfection by Optical Injection
Stevenson, D. J., Gunn-Moore, F. J., Campbell, P. & Dholakia, K., 18 May 2010, The Handbook of Photonics for Biomedical Science. Tuchin, V. (ed.). London: CRC Press, p. 87-117 30 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Enhanced optical micromanipulation and transfection of cells using femtosecond lasers
Brown, C. T. A., Tsampoula, X., Stevenson, D. J., McDougall, C., Gunn-Moore, F. J. & Dholakia, K., 2008, 2008 Digest of the IEEE/LEOS Summer Topical Meetings. IEEE, Vol. 2008. p. 75-76 2 p. (IEEE/LEOS Summer Topical Meetings).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Femtosecond cellular transfection using a non-diffracting beam - art. no. 68541L
Tsampoula, X., Garces-Chavez, V., Comrie, M., Stevenson, D. J., Agate, B., Brown, C. T. A., Gunn-Moore, F. & Dholakia, K., 2008, SPIE. Vol. 6854. p. 8541-8541 10 p.
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Articles
Alzheimer’s disease-like neuropathology in three species of oceanic dolphin
Vacher, M. C., Durrant, C. S., Rose, J., Hall, A. J., Spires-Jones, T. L., Gunn-Moore, F. & Dagleish, M. P., 1 Apr 2023, In: European Journal of Neuroscience. 57, 7, p. 1161-1179 19 p.
Research output: Contribution to journal › Article › peer-review
Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation
Benek, O., Vaskova, M., Miskerikova, M., Schmidt, M., Andrys, R., Rotterova, A., Skarka, A., Hatlapatkova, J., Karasova, J. Z., Medvecky, M., Hroch, L., Vinklarova, L., Fisar, Z., Hroudova, J., Handl, J., Capek, J., Rousar, T., Kobrlova, T., Dolezal, R., Soukup, O., & 3 others, 5 Oct 2023, In: European Journal Of Medicinal Chemistry. 258, 18 p., 115593.
Research output: Contribution to journal › Article › peer-review
The mitochondrial enzyme 17βHSD10 modulates ischemic and amyloid-β-induced stress in primary mouse astrocytes
Metodieva, V., Smith, T. K. & Gunn-Moore, F. J., 12 Sept 2022, In: eNeuro. 9, 5, 24 p.
Research output: Contribution to journal › Article › peer-review
Willin/FRMD6 mediates mitochondrial dysfunction relevant to neuronal Aβ toxicity
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 6 Oct 2022, In: Cells. 11, 19, 27 p., 3140.
Research output: Contribution to journal › Article › peer-review
Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 4 Nov 2021, In: Cells. 10, 11, 27 p., 3024.
Research output: Contribution to journal › Review article › peer-review
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment
Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 26 p., 2059.
Research output: Contribution to journal › Article › peer-review
Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease
Dey, M., Gunn-Moore, F. J., Platt, B. & Smith, T. K., 31 Aug 2020, In: Lipids in Health and Disease. 19, 17 p., 201.
Research output: Contribution to journal › Article › peer-review
Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease
Vinklarova, L., Schmidt, M., Benek, O., Kuca, K., Gunn-Moore, F. & Musilek, K., 23 May 2020, (E-pub ahead of print) In: Journal of Neurochemistry. Early view
Research output: Contribution to journal › Review article › peer-review
Nanostructural diversity of synapses in the mammalian spinal cord
Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F. E., Nylk, J., Dholakia, K., Gunn-Moore, F. J., Grant, S. G. N. & Miles, G. B., 18 May 2020, In: Scientific Reports. 10, 18 p., 8189.
Research output: Contribution to journal › Article › peer-review
Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function
Cheng, Y., Buchan, M., Vitanova, K., Aitken, L., Gunn-Moore, F. J., Ramsay, R. R. & Doherty, G., 13 Oct 2020, In: Journal of Neurochemistry. 155, 2, p. 191-206 e15003.
Research output: Contribution to journal › Article › peer-review
Other publications
Microlensed Fiber-based Poration
Dholakia, K., Ma, N., Ashok, P. C., Stevenson, D. J. & Gunn-Moore, F. J., 3 Jan 2023, Patent No. 2801671
Research output: Patent
Author Correction: Nanostructural Diversity of Synapses in the Mammalian Spinal Cord (Scientific Reports, (2020), 10, 1, (8189), 10.1038/s41598-020-64874-9)
Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F., Nylk, J., Dholakia, K., Gunn-Moore, F., Grant, S. G. N. & Miles, G. B., Dec 2021, In: Scientific Reports. 11, 1, 23160.
Research output: Contribution to journal › Comment/debate › peer-review
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment
Hroch, L., Benek, O., Guest, P., Aitken, L., Soukup, O., Janockova, J., Musil, K., Dohnal, V., Dolezal, R., Kuca, K., Smith, T. K., Gunn-Moore, F. J. & Musilek, K., 1 Aug 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 15, p. 3675-3678 4 p.
Research output: Contribution to journal › Letter › peer-review
Growing old is not for wimps
Gunn-Moore, F. J. & Gunn-Moore, D., 2010, In: Journal of Feline Medicine and Surgery. 12, 11, p. 835-836
Research output: Contribution to journal › Editorial › peer-review
Violet diode-assisted photoporation and transfection of cells
Paterson, L., Agate, B., Comrie, M., Ferguson, R., Stevenson, D., Lake, T., Brown, C., Gunn-Moore, F. J., Riches, A. C., Bryant, P. E., Sibbett, W. & Dholakia, K., Aug 2005
Research output: Other contribution
Axo-glial interactions during myelination.
Perrine, C., Tait, S., Barbin, G., Gunn-Moore, F. J., Girault, JA., Denissenko-Nehrbass, NI., Guennoc, AM., Zalc, B., Brophy, PJ. & Lubetzki, C., 2002
Research output: Other contribution
Neurofascin as a glial partner for the paranodin/caspr-contactin axonal complex at the axoglial junction.
Barbin, G., Tait, S., Charles, P., Faivre-Sarraihl, C., Gunn-Moore, F. J., Denisenko-Nehrbass, NI., Guennoc, AM., Girault, JA., Brophy, PJ. & Lubetzki, C., 2002
Research output: Other contribution
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