Lovett
Group Highlights
The group works on applying and developing EPR spectroscopy for studying the structure of proteins and nucleic acids. The technique uses magnetic resonance to measure the interaction between unpaired electrons and analysis reveals nanometre distances and distance distributions. The method requires that proteins and nucleic acids are tagged with the unpaired electrons.
Research
The research projects of the group are broadly based around developing EPR and spin labelling techniques (with a view to flexibility and sensitivity) and applying them to proteins such as calmodulin and nucleic acids like RNA.
Group Members
Elena Mocanu
Hannah Russell
Publications
Chapters
Tuning the properties of nitroxide spin labels for use in electron paramagnetic resonance spectroscopy through chemical modification of the nitroxide framework
Haugland, M., Anderson, E. A. & Lovett, J. E., Dec 2016, Electron Paramagnetic Resonance. Chechik, V. & Murphy, D. (eds.). RSC, Vol. 25. p. 1-34 (Special Periodical Reports; vol. 25).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Articles
Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times
Sowiński, M. P., Gahlawat, S., Lund, B. A., Warnke, A-L., Hopmann, K. H., Lovett, J. E. & Haugland, M. M., 5 Jun 2023, In: Communications Chemistry. 6, 1, 8 p., 111.
Research output: Contribution to journal › Article › peer-review
Design of the elusive proteinaceous oxygen donor copper site suggests a promising future for copper for MRI contrast agents
Shah, A., Taylor, M. J., Molinaro, G., Anbu, S., Verdu, M., Jennings, L., Mikulska, I., Diaz-Moreno, S., El Mkami, H., Smith, G. M., Britton, M. M., Lovett, J. E. & Peacock, A. F. A., 4 Jul 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 27, e2219036120.
Research output: Contribution to journal › Article › peer-review
The photochemical mediated ring contraction of 4H-1,2,6-thiadiazines to afford 1,2,5-thiadiazol-3(2H)-one 1-oxides
Broumidis, E., Thomson, C. G., Gallagher, B., Sotorríos, L., McKendrick, K. G., Macgregor, S. A., Paterson, M. J., Lovett, J. E., Lloyd, G. O., Rosair, G. M., Kalogirou, A. S., Koutentis, P. A. & Vilela, F., 22 Sept 2023, In: Organic Letters. 25, 37, p. 6907-6912 6 p.
Research output: Contribution to journal › Article › peer-review
Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields
Maity, S., Price, B. D., Wilson, C. B., Mukherjee, A., Starck, M., Parker, D., Wilson, M. Z., Lovett, J. E., Han, S. & Sherwin, M. S., 20 Mar 2023, In: Angewandte Chemie International Edition. 62, 13, 9 p., e202212832.
Research output: Contribution to journal › Article › peer-review
Combined pulsed electron double resonance EPR and molecular dynamics investigations of calmodulin suggest effects of crowding agents on protein structures
Stewart, A., Shanmugam, M., Kutta, R., Scrutton, N., Lovett, J. E. & Hay, S., 6 Sept 2022, In: Biochemistry. 61, 17, p. 1735–1742 8 p.
Research output: Contribution to journal › Article › peer-review
DEER data analysis software: a comparative guide
Russell, H., Cura, R. & Lovett, J. E., 1 Jun 2022, In: Frontiers in Molecular Biosciences. 9, 17 p., 915167.
Research output: Contribution to journal › Article › peer-review
Neural networks in pulsed dipolar spectroscopy: a practical guide
Keeley, J., Choudhury, T., Galazzo, L., Bordignon, E., Feintuch, A., Goldfarb, D., Russell, H., Taylor, M. J., Lovett, J. E., Eggeling, A., Fabregas Ibanez, L., Keller, K., Yulikov, M., Jeschke, G. & Kuprov, I., May 2022, In: Journal of Magnetic Resonance. 338, 14 p., 107186.
Research output: Contribution to journal › Article › peer-review
Benchmark test and guidelines for DEER/PELDOR experiments on nitroxide-labeled biomolecules
Schiemann, O., Heubach, C., Abdullin, D., Ackermann, K., Azarkh, M., Bagryanskaya, E., Drescher, M., Endeward, B., Freed, J., Galazzo, L., Goldfarb, D., Hett, T., Esteban Hofer, L., Fábregas Ibáñez, L., Hustedt, E., Kucher, S., Kuprov, I., Lovett, J. E., Meyer, A., Ruthstein, S., & 10 others, 19 Oct 2021, (E-pub ahead of print) In: Journal of the American Chemical Society. Articles ASAP, 16 p.
Research output: Contribution to journal › Article › peer-review
DEER and RIDME measurements of the nitroxide-spin labelled copper-bound amine oxidase homodimer from arthrobacter globiformis
Russell, H., Stewart, R., Prior, C., Oganesyan, V. S., Gaule, T. G. & Lovett, J. E., 29 Mar 2021, (E-pub ahead of print) In: Applied Magnetic Resonance. First Online, 21 p.
Research output: Contribution to journal › Article › peer-review
Versatile para-substituted pyridine lanthanide coordination complexes allow late stage tailoring of complex function
Starck, M., Fradgley, J., De Rosa, D. F., Batsanov, A., Papa, M., Taylor, M., Lovett, J., Lutter, J., Allen, M. & Parker, D., 16 Nov 2021, (E-pub ahead of print) In: Chemistry - A European Journal. Early View, 7 p.
Research output: Contribution to journal › Article › peer-review
Other publications
Determining the structure of the complex between vWF-A of factor B and CD55
Banham, J. E., Abbott, R., Caesar, J., Roversi, P., Jeschke, G., Timmel, C. & Lea, S., Oct 2008, In: Molecular Immunology. 45, 16, p. 4122-4122 1 p.
Research output: Contribution to journal › Abstract › peer-review
Contact
[email protected]
https://www.st-andrews.ac.uk/~jel20/
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