Coote Group
Group Highlights
Research is focused on identifying new treatments for Multi-Drug Resistant (MDR) human pathogens.
Novel treatments can be single therapies or combinations. Combinations can be derived from antibiotics; antibiotic resistance ‘breakers’ eg. Beta-lactamase inhibitors; efflux-pump inhibitors; or repurposed drugs.
Principal organisms tested are Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Fast-growing Mycobacteria and Candida albicans.
In addition to traditional in vitro microbiology techniques eg. MIC, checkerboard and time-kill assays we use an in vivo invertebrate infection model to test for efficacy of novel treatments versus real infections. This model employs the larvae of the Greater Wax moth (Galleria mellonella).
Recent papers
Carbapenem-only combination therapy against multi-drug resistant Pseudomonas aeruginosa: assessment of in vitro and in vivo efficacy and mode of action
Mackay, B., Parcell, B. J., Shirran, S. L. & Coote, P. J., 25 Oct 2022, In: Antibiotics. 11, 11, 19 p., 1467.
Repurposing the anti-viral drug zidovudine (AZT) in combination with meropenem as an effective treatment for infections with multi-drug resistant, carbapenemase-producing strains of Klebsiella pneumoniae
DeSarno, A. E., Parcell, B. J. & Coote, P. J., 14 Oct 2020, (E-pub ahead of print) In: Pathogens and Disease. Advance Article
Dual β-lactam combination therapy for multi-drug resistant Pseudomonas aeruginosa infection: enhanced efficacy in vivo and comparison with monotherapies of penicillin-binding protein inhibition
Siriyong, T., Murray, R. M., Bidgood, L. E., Young, S. A., Wright, F., Parcell, B. J., Voravuthikunchai, S. P. & Coote, P. J., 24 Jun 2019, In: Scientific Reports. 9, 13 p., 9098.
Research
MSc (Res) projects are available :
https://www.st-andrews.ac.uk/biology/prospective/pgr/biomedical-sciences-mscres/
Group Members
Peter Coote
Publications
Chapters
Utility of greater wax moth larva (Galleria mellonella) for evaluating the toxicity and efficacy of new antimicrobial agents
Desbois, A. P. & Coote, P. J., 2012, Advances in Applied Microbiology. Laskin, A. I., Sariaslani, S. & Gadd, G. M. (eds.). San Diego: Elsevier, Vol. 78. p. 25-53 29 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Yeast stress response to food preservations systems
Brul, S., Klis, F. M., de Nobel, H., Oomes, S. J. C. M., Coote, P. & Hellingwerf, K. J., 7 May 2003, Yeasts in Food. Academic Press/Elsevier , p. 193-207 15 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Articles
Repurposing mitomycin C in combination with pentamidine or gentamicin to treat infections with multi-drug resistant (MDR) 3 Pseudomonas aeruginosa
Svedholm, E. L., Bruce, B., Parcell, B. J. & Coote, P. J., 10 Feb 2024, In: Antibiotics. 13, 2, 15 p., 177.
Research output: Contribution to journal › Article › peer-review
Combination therapy with ciprofloxacin and pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: assessment of in vitro and in vivo efficacy and the role of Resistance-Nodulation-Division (RND) efflux pumps
Fletcher, M., McCormack, A., Parcell, B. J. & Coote, P. J., 26 Jul 2023, In: Antibiotics. 12, 8, 18 p., 1236.
Research output: Contribution to journal › Article › peer-review
Carbapenem-only combination therapy against multi-drug resistant Pseudomonas aeruginosa: assessment of in vitro and in vivo efficacy and mode of action
Mackay, B., Parcell, B. J., Shirran, S. L. & Coote, P. J., 25 Oct 2022, In: Antibiotics. 11, 11, 19 p., 1467.
Research output: Contribution to journal › Article › peer-review
In vivo safety assessment of rhodomyrtone, a potent compound, from Rhodomyrtus tomentosa leaf extract
Siriyong, T., Ontong, J. C., Leejae, S., Suwalak, S., Coote, P. J. & Voravuthikunchai, S. P., 31 Jul 2020, In: Toxicology Reports. 7, p. 919-924 6 p.
Research output: Contribution to journal › Article › peer-review
Repurposing the anti-viral drug zidovudine (AZT) in combination with meropenem as an effective treatment for infections with multi-drug resistant, carbapenemase-producing strains of Klebsiella pneumoniae
DeSarno, A. E., Parcell, B. J. & Coote, P. J., 14 Oct 2020, (E-pub ahead of print) In: Pathogens and Disease. Advance Article
Research output: Contribution to journal › Article › peer-review
Dual β-lactam combination therapy for multi-drug resistant Pseudomonas aeruginosa infection: enhanced efficacy in vivo and comparison with monotherapies of penicillin-binding protein inhibition
Siriyong, T., Murray, R. M., Bidgood, L. E., Young, S. A., Wright, F., Parcell, B. J., Voravuthikunchai, S. P. & Coote, P. J., 24 Jun 2019, In: Scientific Reports. 9, 13 p., 9098.
Research output: Contribution to journal › Article › peer-review
Evaluation of greater wax moth larvae, Galleria mellonella, as a novel in vivo model for non-tuberculosis Mycobacteria infections and antibiotic treatments
Entwistle, F. & Coote, P. J., 1 Apr 2018, In: Journal of Medical Microbiology. 67, p. 585-597 13 p., 000696.
Research output: Contribution to journal › Article › peer-review
Steroidal alkaloids and conessine from the medicinal plant Holarrhena antidysenterica restore antibiotic efficacy in a Galleria mellonella model of multidrug-resistant Pseudomonas aeruginosa infection
Siriyong, T., Voravuthikunchai, S. P. & Coote, P. J., 19 Oct 2018, In: BMC Complementary and Alternative Medicine. 18, 10 p., 285.
Research output: Contribution to journal › Article › peer-review
Effective immunosuppression with dexamethasone phosphate in the Galleria mellonella larva infection model resulting in enhanced virulence of Escherichia coli and Klebsiella pneumoniae
Perez Torres, M., Entwistle, F. & Coote, P. J., Aug 2016, In: Medical Microbiology and Immunology. 205, 4, p. 333-342 11 p.
Research output: Contribution to journal › Article › peer-review
Enhancement of antibiotic efficacy against multi-drug resistant Pseudomonas aeruginosa infections via combination with curcumin and 1-(1-Naphthylmethyl)-Piperazine
Ballard, E. & Coote, P. J., 20 May 2016, In: Journal of Antimicrobial Agents. 2, 2, 7 p., 1000116.
Research output: Contribution to journal › Article › peer-review
Other publications
Anti fungal therapy
Coote, P. J. & Harris, M. R., 2011, Patent No. US 2011/0281788 A1
Research output: Patent
Antimicrobial compositions comprising a cationic peptide and a glycylglycine endopeptidase
Coote, P. J. & Graham, S., 2011, Patent No. US 7,943,128 B2
Research output: Patent
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