Bischoff Lab
Group Highlights
The Bischoff lab is interested in how shape and form arise during development. Ultimately, it is the behavior of individual cells, such as cell migration and cell shape change, that underlies the formation of tissues and organs. We aim to understand how cells interpret information to implement different cell behaviours and how different behaviours are coordinated. Furthermore, we study how signalling is transduced into specific activities of the cytoskeleton and how different cytoskeletal activities are coordinated to execute a certain behaviour.
To gain insights into the regulation and coordination of cell behaviours, we study the morphogenesis of the adult abdominal epidermis of Drosophila. Employing a combination of in vivo 4D microscopy and sophisticated genetics, we observe and quantify all cell behaviours after experimental manipulation of the system. This allows us to gain a deeper understanding of morphogenetic processes and the underlying cell behaviours.
Research
- The mechanistic basis of actomyosin contractility.
- Tissue-wide coordination of pulsed contractions.
- Collective cell migration during morphogensis.
- Coordination of cell behaviour during tissue morhogenesis.
- Modelling morphogenesis.
Group Members
Marcus Bischoff (PI)
Jianyi Mai (PhD student)
Aimee Bebbington (PhD student)
Georgia Beeton (PhD student)
Cameron Harrison (MSc Res student)
Jane Lyon (MSc Res student)
Publications
Chapters
In Vivo Imaging of Hedgehog Transport in Drosophila Epithelia
Seijo, I., Guerrero, I. & Bischoff, M., 2015, Methods in Molecular Biology: Hedgehog Signalling Protocols. Riobo, N. (ed.). Springer Science and Business Media, Vol. 1322.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Articles
An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa
Harding, C. J., Bischoff, M., Bergkessel, M. & Melo Czekster, C., 1 Sept 2023, In: Nature Chemical Biology. 19, 9, p. 1158-1166 15 p.
Research output: Contribution to journal › Article › peer-review
Coordination of cytoskeletal dynamics and cell behaviour during Drosophila abdominal morphogenesis
Pulido Companys, P., Norris, A. & Bischoff, M., 30 Mar 2020, In: Journal of Cell Science. 133, 6, 18 p., jcs235325.
Research output: Contribution to journal › Article › peer-review
Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells
Baena-Lopez, L. A., Arthurton, L., Bischoff, M., Vincent, J-P., Alexandre, C. & McGregor, R., 4 Dec 2018, In: Development. 145, 23, 11 p., dev170811.
Research output: Contribution to journal › Article › peer-review
Epidermal growth factor signalling controls Myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis
Saxena, A., Denholm, B., Bunt, S., Bischoff, M., VijayRaghavan, K. & Skaer, H., 2 Dec 2014, In: PLoS Biology. 12, 12, 17 p., e1002013.
Research output: Contribution to journal › Article › peer-review
Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion
Gradilla, A-C., González, E., Seijo, I., Andrés, G., Bischoff, M., González-Mendez, L., Sánchez, V., Callejo, A., Ibáñez, C., Guerra, M., Ortigão-Farias, J. R., Sutherland, J. D., González, M., Barrio, R., Falcón-Pérez, J. M. & Guerrero, I., 4 Dec 2014, In: Nature Communications. 5, 13 p., 5649.
Research output: Contribution to journal › Article › peer-review
The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila
Pérez-Moreno, J. J., Bischoff, M., Martín-Bermudo, M. D. & Estrada, B., Jul 2014, In: Journal of Cell Science. 127, p. 3162-3173
Research output: Contribution to journal › Article › peer-review
Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia
Bischoff, M., Gradilla, A-C., Seijo, I., Andres, G., Rodriguez-Navas, C., Gonzalez-Mendez, L. & Guerrero, I., 2013, In: Nature Cell Biology. 15, p. 1269-1281
Research output: Contribution to journal › Article › peer-review
Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila
Bischoff, M., 1 Mar 2012, In: Developmental Biology. 363, 1, p. 179-190 12 p.
Research output: Contribution to journal › Article › peer-review
Cell rearrangements, cell divisions and cell death in a migrating epithelial sheet in the abdomen of Drosophila
Bischoff, M. & Cseresnyes, Z., 15 Jul 2009, In: Development. 136, 14, p. 2403-2411 9 p.
Research output: Contribution to journal › Article › peer-review
Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions
Bischoff, M., Parfitt, D-E. & Zernicka-Goetz, M., Mar 2008, In: Development. 135, 5, p. 953-962 10 p.
Research output: Contribution to journal › Article › peer-review
Contact
Join us
Are you interested in joining the lab?
Currently, we have no PhD studentships advertised in the Bischoff lab.
We currently also offer MSc(Res) projects “investigating the coordination of cell behaviours during Drosophila morphogenesis” as part of the MSc(Res) Biomedical Sciences degree. More information you can find here.
St Andrews provides a great environment for research and is also a beautiful place to live. The Bischoff lab is keen to help anybody who would like to come to St Andrews to study aspects of Drosophila morphogenesis or, more generally, development.
Postdoctoral researchers who plan to apply for a fellowship to cover their salary costs are encouraged to get in touch with Marcus to discuss possibilities.
PhD studentships in the lab are advertised on FindaPhD.com. Students with their own funding (or wishing to apply for their own funding) should contact Marcus directly.
Master studentships in the lab are advertised on FindaMaster.com and on the pages of the School of Biology.
Undergraduate students wishing to spend the Summer in the lab and who are eligible for vacation studentship funding from the BSDB, Wellcome Trust or other funding bodies should contact Marcus.
Dr. Marcus Bischoff
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
Fife
KY16 9ST
UK
Tel: 01334 467199
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