Lovett
Group Highlights
The group works on applying and developing EPR spectroscopy for studying the structure of proteins and nucleic acids. The technique uses magnetic resonance to measure the interaction between unpaired electrons and analysis reveals nanometre distances and distance distributions. The method requires that proteins and nucleic acids are tagged with the unpaired electrons.
Research
The research projects of the group are broadly based around developing EPR and spin labelling techniques (with a view to flexibility and sensitivity) and applying them to proteins such as calmodulin and nucleic acids like RNA.
Group Members
Elena Mocanu
Hannah Russell
Publications
Chapters
Tuning the properties of nitroxide spin labels for use in electron paramagnetic resonance spectroscopy through chemical modification of the nitroxide framework
Haugland, M., Anderson, E. A. & Lovett, J. E., Dec 2016, Electron Paramagnetic Resonance. Chechik, V. & Murphy, D. (eds.). RSC, Vol. 25. p. 1-34 (Special Periodical Reports; vol. 25).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Articles
Design of a site selective heterochromic bimetallic lanthanide coiled coil with nanometre-scale control
Slope, L. N., Shah, A., Taylor, M. J., Borghesani, V., Caulton, S. G., Brooks, N. J., Hadley, K. A., Rose, G., Hunter, R. I., Mkami, H. E. L., Smith, G. M., Leney, A. C., Buurma, N. J., Lovering, A. L., Lovett, J. E. & Peacock, A. F. A., 12 May 2026, (E-pub ahead of print) In: Chemical Science. Advance Article, p. 1-11 11 p.
Research output: Contribution to journal › Article › peer-review
Double electron-electron resonance (DEER) structural study of the holo and apo states of calmodulin
Fisher, S. R., Mocanu, E. M., Shah, A. & Lovett, J. E., 16 Jun 2026, (E-pub ahead of print) In: International Journal of Radiation Biology. Latest Articles, 11 p.
Research output: Contribution to journal › Article › peer-review
Optimized lanthanide(III) tags for rapid and efficient protein labeling in electron paramagnetic resonance and luminescence applications
Topping, L., Mocanu, E. M., Fisher, S. R., Hunter, R. I., Ben‐Ishay, Y., Goldfarb, D., Smith, G. M., Lovett, J. E. & Butler, S. J., 10 Jan 2026, In: Chemistry Europe. 4, 1, 9 p., e202500282.
Research output: Contribution to journal › Article › peer-review
Robustness and sensitivity of Gd(III)-Gd(III) double electron electron resonance (DEER) measurements: comparative study of high-frequency EPR spectrometer designs and spin label variants
Mocanu, E. M., Ben-Ishay, Y., Topping, L., Fisher, S. R., Hunter, R. I., Su, X.-C., Butler, S., Smith, G. M., Goldfarb, D. & Lovett, J. E., 1 May 2025, In: Applied Magnetic Resonance. 56, 5, p. 591-611 21 p.
Research output: Contribution to journal › Article › peer-review
Sigmatropic rearrangement enables access to a highly stable spirocyclic nitroxide for protein spin labelling
Sowiński, M. P., Mocanu, E. M., Ruskin-Dodd, H., McKay, A. P., Cordes, D. B., Lovett, J. E. & Haugland-Grange, M., 7 May 2025, In: Chemical Communications. 61, 37, p. 6755-6758 4 p.
Research output: Contribution to journal › Article › peer-review
Spirocyclic pyrrolidinyl nitroxides with exo-methylene substituents
Sowiński, M. P., Warnke, A.-L., Lund, B. A., Skagseth, S., Cordes, D. B., Lovett, J. E. & Haugland, M. M., 13 Dec 2024, In: ChemPlusChem. 89, 12, 7 p., e202400387.
Research output: Contribution to journal › Article › peer-review
Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times
Sowiński, M. P., Gahlawat, S., Lund, B. A., Warnke, A.-L., Hopmann, K. H., Lovett, J. E. & Haugland, M. M., 5 Jun 2023, In: Communications Chemistry. 6, 1, 8 p., 111.
Research output: Contribution to journal › Article › peer-review
Design of the elusive proteinaceous oxygen donor copper site suggests a promising future for copper for MRI contrast agents
Shah, A., Taylor, M. J., Molinaro, G., Anbu, S., Verdu, M., Jennings, L., Mikulska, I., Diaz-Moreno, S., El Mkami, H., Smith, G. M., Britton, M. M., Lovett, J. E. & Peacock, A. F. A., 4 Jul 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 27, e2219036120.
Research output: Contribution to journal › Article › peer-review
The photochemical mediated ring contraction of 4H-1,2,6-thiadiazines to afford 1,2,5-thiadiazol-3(2H)-one 1-oxides
Broumidis, E., Thomson, C. G., Gallagher, B., Sotorríos, L., McKendrick, K. G., Macgregor, S. A., Paterson, M. J., Lovett, J. E., Lloyd, G. O., Rosair, G. M., Kalogirou, A. S., Koutentis, P. A. & Vilela, F., 22 Sept 2023, In: Organic Letters. 25, 37, p. 6907-6912 6 p.
Research output: Contribution to journal › Article › peer-review
Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields
Maity, S., Price, B. D., Wilson, C. B., Mukherjee, A., Starck, M., Parker, D., Wilson, M. Z., Lovett, J. E., Han, S. & Sherwin, M. S., 20 Mar 2023, In: Angewandte Chemie International Edition. 62, 13, 9 p., e202212832.
Research output: Contribution to journal › Article › peer-review
Other publications
Determining the structure of the complex between vWF-A of factor B and CD55
Banham, J. E., Abbott, R., Caesar, J., Roversi, P., Jeschke, G., Timmel, C. & Lea, S., Oct 2008, In: Molecular Immunology. 45, 16, p. 4122-4122 1 p.
Research output: Contribution to journal › Abstract › peer-review
Contact
[email protected]
https://www.st-andrews.ac.uk/~jel20/
Related themes:
Related Centre: