V Anne Smith

Peter Woodbridge
Monday 16 September 2024


Research Centre:



Group Highlights


My research is in the field of computational biology. I examine complex biological networks, developing and evaluating algorithms to infer functional interactions based upon observational data. I develop advances for and work with agent-based models and Bayesian networks.

See my Research Page for more detail about my research and the biological networks which I study. I have also provided some background for the computational methods with which I work.



Research


  • Computational Biology
  • Complex Biological Networks
  • Simulation Framework for Evaluation of Algorithms

Group Members


  • V Anne Smith
  • Jacob Francis
  • Edwin Hui
  • Emiliano Videla Rodriguez
  • Madeleine Clarkson
  • Emma Puranen
  • Xuejia Ke
  • Lily Bates
  • Lara Jost
  • Nicola Simonetti

Publications

Books

1st Year Practicals: Their Role in Developing Future Bioscientists
Adams, D., Arkle, S., Bevan, R., Boachie-Ansah, G., Bradshaw, T., Cameron, G., Campbell, A.-M., Chamberlain, M., Gibson, A., Gowers, D., Hayes, M., Heritage, J., Hollingsworth, M., Hooper, H., Hudson, K., Hughes, I., Lindsey, N., Meskin, S., Park, J. & Podesta, T. & 12 others, Rattray, J., Scott, G., Shearer, M. C., Smalley, H., Smith, V. A., Smith, D., Tierney, A., Todd, M., Verran, J., Wakeford, C., Wilbraham, J. & Wilson, J., Jun 2008, Unknown Publisher.
Research output: Book/ReportCommissioned report

 

Chapters

Genes identified via Bayesian network analysis of temporal dynamic expression are prognostic of survival in ovarian cancer
Currant, H., Vogogias, A. & Smith, V. A., 20 Jul 2021, (Accepted/In press) 15th Bayesian Modeling Applications Workshop. (CEUR workshop proceedings).
Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biological network inference at multiple scales: from gene regulation to species interactions
Aderhold, A., Smith, V. A. & Husmeier, D., 2016, Pattern Recognition in Computational Molecular Biology: Techniques and Approaches. Elloumi, M., Iliopoulos, C. S., Wang, J. T. L. & Zomaya, A. Y. (eds.). Wiley-Blackwell, p. 525-554 (Wiley Book Series on Bioinformatics: Computational Techniques and Engineering).
Research output: Chapter in Book/Report/Conference proceedingChapter

MLCut: exploring Multi-Level Cuts in dendrograms for biological data
Vogogias, A., Kennedy, J., Archaumbault, D., Smith, V. A. & Currant, H., 16 Sept 2016, Computer Graphics and Visual Computing Conference (CGVC) 2016. Turkay, C. & Wan, T. R. (eds.). Eurographics Association
Research output: Chapter in Book/Report/Conference proceedingConference contribution

Inference of circadian regulatory networks
Grzegorczyk, M., Aderhold, A., Smith, V. A. & Husmeier, D., 2014, Proceedings of the 2nd International Work-Conference on Bioinformatics and Biomedical Engineering. Copicentro Granada S L, p. 1001-1014
Research output: Chapter in Book/Report/Conference proceedingConference contribution

Assessment of Regression Methods for inference of regulatory networks involved in circadian regulation
Aderhold, A., Husmeier, D., Smith, V. A., Millar, A. J. & Grzegorczyk, M., 2013, Proceedings of the 10th International Workshop on Computational Systems Biology. p. 29-33
Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cancer systems biology
Faratian, D., Bown, J., Smith, V. A., Langdon, S. & Harrison, D. J., 2010, Systems Biology in Drug Discovery and Development: Methods and Protocols. Yan, Q. (ed.). 1 ed. Springer, p. 245-263 (Methods in Molecular Biology; vol. 662).
Research output: Chapter in Book/Report/Conference proceedingChapter

Some useful mathematical tools to transform microarray data into interactive molecular networks
Matthäus, F., Smith, V. A. & Gebicke-Haerter, P. J., May 2010, Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling. Tretter, F., Winterer, G., Gebicke-Haerter, P. J. & Mendoza, E. (eds.). Wiley-Blackwell
Research output: Chapter in Book/Report/Conference proceedingChapter

 

Articles

Bayesian networks for network inference in biology
Hammond, J. & Smith, V. A., 7 May 2025, In: Journal of the Royal Society Interface. 22, 226, p. 1-10 10 p., 20240893.
Research output: Contribution to journalReview articlepeer-review

Evaluation of Bayesian network scoring functions in polychotomous data analysis
Ke, X., Keenan, K. L. & Smith, V. A., Dec 2025, In: Discover Data. 3, 1, p. 1-21 21 p., 18.
Research output: Contribution to journalArticlepeer-review

Patterns of antibiotic resistance in urinary tract infections before and during the COVID-19 pandemic in Uganda and Tanzania
Silago, V., Keenan, K., Mushi, M. F., Kansiime, C., Asiimwe, B., Sunday, B., Bazira, J., Sandeman, A., Sabiiti, W., Seni, J., Holden, M. T. G., Mshana, S. E. & behalf of the HATUA and CARE Consortia, Apr 2025, In: JAC-Antimicrobial Resistance. 7, 2, p. 1-4 4 p., dlaf038.
Research output: Contribution to journalArticlepeer-review

A two-step Bayesian network approach to identify key SNPs associated to multiple phenotypic traits in four purebred laying hen lines
Bouba, I., Videla Rodriguez, E. A., Smith, V. A., van den Brand, H., Rodenburg, T. B. & Visier, B., 29 Mar 2024, In: PLoS ONE. 19, 3, 18 p., e0297533.
Research output: Contribution to journalArticlepeer-review

Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use
Keenan, K. L., Papathomas, M., Mshana, S., Asiimwe, B., Kiiru, J., Lynch, A., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Jing, W., Green, D. L., Olamijuwon, E. O., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Bazira, J. & Sloan, D. J. & 8 others, HATUA Consortium, Kibiki, G., Mmbaga, B. T., Aanensen, D., Stelling, J., Smith, V. A., Sandeman, A. & Holden, M., 31 Oct 2024, In: Nature Communications. 15, 11 p., 9418.
Research output: Contribution to journalArticlepeer-review

Robust identification of interactions between heat-stress responsive genes in the chicken brain using Bayesian networks and augmented expression data
Videla Rodriguez, E. A., Mitchell, J. B. O. & Smith, V. A., 19 Apr 2024, In: Scientific Reports. 14, 8 p., 9019.
Research output: Contribution to journalArticlepeer-review

Science fiction media representations of exoplanets: portrayals of changing astronomical discoveries
Puranen, E., Finer, E., Helling, C. & Smith, V. A., 4 Mar 2024, In: Journal of Science Communication. 23, 1, 19 p., A04.
Research output: Contribution to journalArticlepeer-review

Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: a study of urinary tract infection patients in Kenya, Tanzania and Uganda
Sado, K., Keenan, K., Manataki, A., Kesby, M., Mushi, M. F., Mshana, S. E., Mwanga, J. R., Neema, S., Asiimwe, B., Bazira, J., Kiiru, J., Green, D. L., Ke, X., Maldonado-Barragán, A., Abed Al Ahad, M., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Mmbaga, B. T. & Kibiki, G. & 6 others, Aanensen, D., Smith, V. A., Sandeman, A., Sloan, D. J., Holden, M. T. G. & Consortium, O. B. O. H., 16 Feb 2024, In: PLOS Global Public Health. 4, 2, 20 p., e0002709.
Research output: Contribution to journalArticlepeer-review

The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda
Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Abed Al Ahad, M., Olamijuwon, E., Aduda, A., Njeru, J. M., Mmbaga, B. T. & Bazira, J. & 8 others, Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Holden, M. T. G. & HATUA Consortium, 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.
Research output: Contribution to journalArticlepeer-review

A Bayesian network structure learning approach to identify genes associated with stress in spleens of chickens
Videla Rodriguez, E. A., Mitchell, J. B. O. & Smith, V. A., 6 May 2022, In: Scientific Reports. 12, 8 p., 7482.
Research output: Contribution to journalArticlepeer-review

 

Papers

Evolving an agent-based model to probe behavioral rules in flocks of cowbirds
Smith, V. A., 2008, p. 561-568.
Research output: Contribution to conferencePaper

The CARMEN e-Science pilot project: Neuroinformatics work packages
Smith, L. S., Austin, J., Baker, S., Borisyuk, R., Eglen, S., Feng, J., Gurney, K., Jackson, T., Kaiser, M., Overton, P., Panzeri, S., Quian Quiroga, R., Schultz, S. R., Sernagor, E., Smith, V. A., Smulders, T. V., Stuart, L., Whittington, M., Ingram, C. & Cox, S. J., Sept 2007, p. 591-598.
Research output: Contribution to conferencePaper

Influence of network topology and data collection on network inference
Smith, V. A., Jarvis, E. D., Hartemink, A. J., Altman, R. B., Dunker, A. K., Hunter, L., Jung, T. A. & Klien, T. E., 2003, p. 164-175.
Research output: Contribution to conferencePaper

Using Bayesian network inference algorithms to recover molecular genetic regulatory networks
Yu, J., Smith, V. A., Wang, P. P., Hartemink, A. J. & Jarvis, E. D., Dec 2002.
Research output: Contribution to conferencePaper

 

Other publications

The scientific method: teaching the how of science and not just the what
Shearer, M. C. & Smith, V. A., 2007, In: Centre for Bioscience Bulletin. 21, p. 8 8 p.
Research output: Contribution to journalSpecial issuepeer-review

 



Contact

School of Biology

Sir Harold Mitchell Building
University of St Andrews
St Andrews, Fife
KY16 9TH
United KingdomEmail: [email protected]
Phone: +44 (0)1334 463368


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