{"id":12,"date":"2022-01-13T15:41:34","date_gmt":"2022-01-13T15:41:34","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?page_id=12"},"modified":"2022-12-01T11:33:57","modified_gmt":"2022-12-01T11:33:57","slug":"research-groups","status":"publish","type":"page","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-groups\/","title":{"rendered":"Research Groups"},"content":{"rendered":"
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Alan Stewart Group – Metal ions in Medicine<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our work is centred on how metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling can lead to disease.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Andy Gardner<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

I work on Darwinian adaptation. Natural selection explains the appearance of design in the living world, but at what level is this design expected to manifest \u2013 gene, individual, society \u2013 and what is its function?<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Centre for Biological Diversity<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Bela Bode<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

The group’s research focusses on using Electron Paramagnetic Resonance (EPR) spectroscopy to study the microscopic structure and dynamics of (bio)molecules and materials.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Biodiversity and behaviour<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We conduct research on a wide range of taxa including corals, fish, birds, aquatic invertebrates, and plants.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Centre for Biological Diversity<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Bischoff Lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We are interested in how shape and form arise during animal development. During morphogenesis, cells interpret complex information and react accordingly to shape tissues and organs. Here, many cell behaviours, such as cell migration and cell shape changes, work together. Despite recent progress, it still remains mysterious how all these behaviours are regulated and coordinated.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Coote Group<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Research is focused on identifying new treatments for Multi-Drug Resistant (MDR) human pathogens.
\nNovel treatments can be single therapies or combinations. Combinations can be derived from antibiotics; antibiotic resistance ‘breakers’ eg. Beta-lactamase inhibitors; efflux-pump inhibitors; or repurposed drugs.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

CRISPR and DNA Repair Systems<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Cells must defend their genomes against attack by selfish genetic elements such as viruses. Although CRISPR is widely known as a genome editing technology, the CRISPR system functions as an adaptive immune system in prokaryotes.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Czekster Lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our research combines enzymology, structural biology, chemical biology and microbiology to understand how bacteria produce and use cyclic peptides in interspecies and interkingdom warfare and\/or cooperation. Our purpose is to generate novel drugs, probes, carriers, and technologies that will allow us to control and modulate bacterial populations.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

da Silva lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

In the da Silva Lab, we apply techniques of molecular biology, biochemistry, structural biology and physical organic chemistry to unravel the mechanisms of enzymatic reactions catalysed by multi-protein allosteric complexes, tRNA methyltranferases, and nucleotide hydrolases. Particular attention is given to transition-state structure, inhibitor design, and fast protein dynamics.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Evolutionary Developmental Genomics (EDGe) Group<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We aim to understand how the diversity of animal form develops and evolved. The focus of our research is the connection between the content and organisation of genomes to the evolution of development (evo-devo).\u00a0 The homeobox-containing genes of the Hox gene cluster have been a corner-stone of Evolutionary Developmental Biology, but much about cluster organisation and mode of operation remains unknown.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Scottish Oceans Institute<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Ferreira Group<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our aim is to gain mechanistic insight into chromatin remodelling enzymes relevant to human health \u2013 to promote the generation of new translational therapies.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Gunn-Moore<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

My group has made major discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer\u2019s disease (linking mitochondrial and synaptic dysfunction), where we have pioneered new models (including the first identification that cetaceans also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors (filed patents).<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Healy Lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Centre for Biological Diversity<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Hughes Lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our research aims to understand how people, and other animals, defend themselves against viral infections and how viruses are able to overcome these defences. This knowledge can then inform the development of therapeutics.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Insect Behavioural Ecology<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We study the evolution and ecology of insect behaviour, particularly sexual and reproductive behaviour.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Centre for Biological Diversity<\/a><\/div>\r\n\t<\/div>
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\r\n \"Description\"\r\n

Jens Tilsner<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our group investigates the structure and function of nano-channels connecting plant cells (plasmodesmata), and how these are hijacked by plant viruses to spread through the host.
\nWe use molecular biology, biochemistry, structural biology, live cell and super-resolution imaging, electron microscopy, reverse and forward genetics, and transient and stable plant transformation to address these questions.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Judith Sleeman<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We study the maturation of snRNP splicing factors and the transport of mature mRNA, with a particular emphasis on their dynamics within the nucleus and differences between neural and non-neural cell types that may be significant for SMA.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Lovett<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

The group works on applying and developing EPR spectroscopy for studying the structure of proteins and nucleic acids. The technique uses magnetic resonance to measure the interaction between unpaired electrons and analysis reveals nanometre distances and distance distributions. The method requires that proteins and nucleic acids are tagged with the unpaired electrons.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Mitchell Group<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We are an Informatics and Computational Chemistry research group. Our group is based in the Purdie building on the North Haugh in St Andrews. Research areas we are interested in are machine learning, aqueous solubility, enzyme catalysis, protein-ligand interactions, modelling epidemics, molecular evolution and structural bioinformatics, computational toxicology, prediction of solubility and other molecular properties, and the classification of drugs used for doping in sport.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Neurogenetics of Vocal Communication<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our research group focuses on the study of vocal communication in mammals as a way to understand the biological basis of human speech and language and how this trait evolved.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Sediment Ecology Research Group<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

The Sediment Ecology Research Group (SERG), known popularly as \u201cThe Mud Lab\u201d of the Scottish Oceans Institute, University of St Andrews specialises in the investigation of the ecology of aquatic systems, with emphasis on marine and estuarine coasts, shallow marine systems and salt marshes.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Scottish Oceans Institute<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Somorjai Lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We are interested in studying development in a comparative evolutionary context, with particular reference to chordates. We use the cephalochordate amphioxus as our main study species due to its relative genomic and morphological simplicity, and its phylogenetic position basal to the vertebrates.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

The Gloster laboratory<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We are interested in understanding eukaryotic carbohydrate processing enzymes from a structural, mechanistic and functional viewpoint using a combination of techniques including molecular biology, protein expression, X-ray crystallography, enzyme kinetics, inhibitor design\/development and cell biology.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

The Goss lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We are interested in understanding biosynthetic processes at the molecular level and combining the tools of organic synthesis, molecular biology and protein biochemistry to generate new natural products of our own design.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

The Lala lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Our work is highly interdisciplinary, lying on the interface of evolutionary biology, animal behaviour, ecology and psychology, and combines a wide variety of empirical and theoretical approaches.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Centre for Biological Diversity<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

The MacNeill Lab<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Research in the MacNeill lab is primarily focused on using molecular genetic tools to probe protein structure, function and regulation in various microbial model systems. In addition to molecular genetic methods, we use biochemistry, structural biology and bioinformatics.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

TKS<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

Prof Terry Smith is an expert in phospholipid metabolism and the use of mass spectrometry techniques and heads the Lipidomics Facility with GC-MSs and ABSciex 4000 QTrap for lipidomic and focussed metabolomics.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

Uli Schwarz-Linek<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

We use structural biology (NMR, X-ray crystallography, cryo-EM) combined with cell-based assays, biophysical and biochemical methods to investigate the molecular basis for interactions between pathogens and hosts. We focus on surface proteins of Gram-positive bacteria and interferon antagonists of negative-strand RNA viruses.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
Category <\/span>Biomedical Sciences Research Complex<\/a><\/div>\r\n\t<\/div>
\r\n\r\n\r\n\r\n
\r\n \"Description\"\r\n

V Anne Smith<\/a><\/h3>\r\n\t\t<\/div>\r\n\t\t

My research is in the field of computational biology. I examine complex biological networks, developing and evaluating algorithms to infer functional interactions based upon observational data.<\/p>\n<\/p><\/div>\r\n

Date <\/span><\/div>\r\n
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