{"id":184,"date":"2022-09-08T10:29:31","date_gmt":"2022-09-08T09:29:31","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&#038;p=184"},"modified":"2022-12-21T10:18:53","modified_gmt":"2022-12-21T10:18:53","slug":"da-silva-lab","status":"publish","type":"research_group","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-group\/da-silva-lab\/","title":{"rendered":"da Silva lab"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-328 size-full\" src=\"https:\/\/dasilva.wp.st-andrews.ac.uk\/files\/2022\/06\/Picture3.jpg\" alt=\"\" width=\"1280\" height=\"164\" \/><\/p>\n<p>Enzymes catalyse virtually all chemical reactions in living organisms, making their rates compatible with life. These proteins have evolved to utilize a range of strategies to achieve incredible rate enhancements in comparison with the corresponding non-catalysed reactions. The study of enzymatic mechanisms is fundamental to elucidate how enzymes work in physical and chemical terms, and how their activity is regulated.<\/p>\n<p>In the da Silva Lab, we apply techniques of molecular biology, biochemistry, structural biology and physical organic chemistry to unravel the mechanisms of enzymatic reactions catalysed by multi-protein allosteric complexes, tRNA methyltranferases, and nucleotide hydrolases. Particular attention is given to transition-state structure, inhibitor design, and fast protein dynamics.<\/p>\n<p>We are part of the<span>\u00a0<\/span><a title=\"BSRC\" href=\"http:\/\/www.st-andrews.ac.uk\/bsrc\/\" target=\"_blank\" rel=\"noopener\">Biomedical Sciences Research Complex<\/a><span>\u00a0<\/span>and the<span>\u00a0<\/span><a title=\"School of Biology\" href=\"http:\/\/biology.st-andrews.ac.uk\/\" target=\"_blank\" rel=\"noopener\">School of Biology<\/a><span>\u00a0<\/span>at the<span>\u00a0<\/span><a title=\"University of St Andrews\" href=\"http:\/\/www.st-andrews.ac.uk\/\" target=\"_blank\" rel=\"noopener\">University of St\u00a0Andrews<\/a>. Our lab is located in the BMS Annexe Building on North Haugh.<\/p>\n<p>Our lab website: https:\/\/dasilva.wp.st-andrews.ac.uk\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the da Silva Lab, we apply techniques of molecular biology, biochemistry, structural biology and physical organic chemistry to unravel the mechanisms of enzymatic reactions catalysed by multi-protein allosteric complexes, tRNA methyltranferases, and nucleotide hydrolases. Particular attention is given to transition-state structure, inhibitor design, and fast protein dynamics.<\/p>\n","protected":false},"author":69,"featured_media":185,"parent":0,"menu_order":0,"template":"","class_list":["post-184","research_group","type-research_group","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"group_members":false,"publications":false,"research_projects":false,"related_theme":false,"related_centre":false,"contact":false,"_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group\/184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/types\/research_group"}],"author":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/users\/69"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media\/185"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media?parent=184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}