{"id":194,"date":"2022-09-16T15:23:58","date_gmt":"2022-09-16T14:23:58","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&#038;p=194"},"modified":"2022-12-21T10:29:56","modified_gmt":"2022-12-21T10:29:56","slug":"uli-schwarz-linek","status":"publish","type":"research_group","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-group\/uli-schwarz-linek\/","title":{"rendered":"Uli Schwarz-Linek"},"content":{"rendered":"<p><span>Bacteria and viruses use proteins (virulence factors) to colonise their hosts, avoid the immune system, and spread in infected organisms. We use structural biology (NMR, X-ray crystallography, cryo-EM) combined with cell-based assays, biophysical and biochemical methods to investigate the molecular basis for interactions between pathogens and hosts. We focus on surface proteins of Gram-positive bacteria and interferon antagonists of negative-strand RNA viruses. Our most important discoveries to date:<\/span><\/p>\n<ul>\n<li><span>Identification and characterisation of TIE proteins as a common class of adhesins of Gram-positive bacteria<\/span><\/li>\n<li><span>Covalent binding of bacterial TIE proteins to a host protein<\/span><\/li>\n<li><span>Structural basis of intranuclear filament formation of Rift Valley fever phlebovirus NSs protein<\/span><\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-196\" src=\"https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/09\/strep_TIE_fibrin_Ulrich-Schwarz-Linek-300x215.jpg\" alt=\"\" width=\"300\" height=\"215\"><\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We use structural biology (NMR, X-ray crystallography, cryo-EM) combined with cell-based assays, biophysical and biochemical methods to investigate the molecular basis for interactions between pathogens and hosts. We focus on surface proteins of Gram-positive bacteria and interferon antagonists of negative-strand RNA viruses.<\/p>\n","protected":false},"author":79,"featured_media":195,"parent":0,"menu_order":0,"template":"","class_list":["post-194","research_group","type-research_group","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"group_members":"<p><a href=\"https:\/\/risweb.st-andrews.ac.uk\/portal\/en\/persons\/manon-delaplace(628be41a-74cf-4205-9bdb-b67d683c3e3f).html\"><span>Dr Manon Delaplace<\/span><\/a> <span>Grant Watt<\/span><\/p>","publications":"[publications flag='individual' code='us6' dois='1' max='10' categorise='1']","research_projects":"<p><span>Structures and binding targets of TIE proteins<\/span> <span>Structures of group A streptococcal M proteins and their interactions with host extracellular matrix components<\/span> <span>Molecular basis of Rift Valley fever phlebovirus NSs protein (MRC funded)<\/span><\/p>","related_theme":[{"related_groups":[59,194,218,165,239],"related_centre":77,"ID":93,"post_title":"Infection and immunity","post_content":"<span>BSRC infection biologists\u2019 study basic and applied aspects of viral, bacterial and parasite pathogens. Their research includes fundamental studies of pathogen replication and host interactions, antimicrobial resistance, therapeutic drug design and testing, and clinical and real-time diagnostics.<\/span>","post_excerpt":"BSRC infection biologists\u2019 study basic and applied aspects of viral, bacterial and parasite pathogens. Their research includes fundamental studies of pathogen replication and host interactions, antimicrobial resistance, therapeutic drug design and testing, and clinical and real-time diagnostics.","post_author":"4","post_date":"2022-01-18 01:47:43","post_date_gmt":"2022-01-18 01:47:43","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"infection-and-immunity","to_ping":"","pinged":"","post_modified":"2022-02-25 14:07:17","post_modified_gmt":"2022-02-25 14:07:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&#038;p=93","menu_order":0,"post_type":"research_theme","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["137","4","2022-02-25 14:07:10","2022-02-25 14:07:10","","IMG_7497-Edit","","inherit","open","closed","","img_7497-edit","","","2022-02-25 14:07:10","2022-02-25 14:07:10","","93","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/01\/IMG_7497-Edit.jpg","0","attachment","image\/jpeg","0","137"],"id":93}],"related_centre":[{"ID":77,"post_title":"Biomedical Sciences Research Complex","post_content":"<span>The\u00a0Biomedical Sciences Research Complex (BSRC) is an interdisciplinary centre for biomedical research with contributions from the Schools of Biology, Chemistry, Medicine, Physics and Astronomy.\u00a0The BSRC's main research themes are infection and immunity, biophysics, molecular medicine, and chemical biology.\u00a0<\/span>\r\n\r\n<a href=\"https:\/\/biology.st-andrews.ac.uk\/bsrc\">Main Website<\/a>","post_excerpt":"","post_author":"4","post_date":"2022-01-17 15:53:50","post_date_gmt":"2022-01-17 15:53:50","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biomedical-sciences-research-complex","to_ping":"","pinged":"","post_modified":"2022-09-20 13:31:47","post_modified_gmt":"2022-09-20 12:31:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_centre&#038;p=77","menu_order":0,"post_type":"research_centre","post_mime_type":"","comment_count":"0","comments":false,"id":77}],"contact":"<p><span>Dr Uli Schwarz-Linek<\/span><\/p>\r\n<p><span>Biomedical Sciences Research Complex<\/span><\/p>\r\n<p><span>University of St Andrews<\/span><\/p>\r\n<p><span>us6@st-andrews.ac.uk<\/span> \u00a0<\/p>\r\n<p><span>twitter @UliSchwarzLinek<\/span><\/p>\r\n<p><a href=\"https:\/\/orcid.org\/0000-0003-0526-223X\"><span>https:\/\/orcid.org\/0000-0003-0526-223X<\/span><\/a>\u00a0<\/p>\r\n<p>&nbsp;<\/p>\r\n<p><a class=\"twitter-follow-button\" href=\"https:\/\/twitter.com\/UliSchwarzLinek?ref_src=twsrc%5Etfw\" data-show-count=\"false\">Follow @UliSchwarzLinek<\/a><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>","_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group\/194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/types\/research_group"}],"author":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/users\/79"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media\/195"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media?parent=194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}