{"id":210,"date":"2022-11-28T15:55:52","date_gmt":"2022-11-28T15:55:52","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&p=210"},"modified":"2022-12-21T10:20:37","modified_gmt":"2022-12-21T10:20:37","slug":"gunn-moore","status":"publish","type":"research_group","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-group\/gunn-moore\/","title":{"rendered":"Gunn-Moore"},"content":{"rendered":"

My group has made major discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer\u2019s disease (linking mitochondrial and synaptic dysfunction), where we have pioneered new models (including the first identification that cetaceans also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors (filed patents). Using both molecular and novel biophysical techniques, we have also discovered novel biochemical pathways that are involved in the growth and development of mammalian neurons. These findings include the first identification of the protein FRMD6\/Willin as an upstream component of the Hippo pathway, which prior to our work, was thought to be involved only in cancer, but we have now linked its activity to Alzheimer\u2019s disease progression.<\/span><\/p>\n

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I always claim that we are truly interdisciplinary, as we have published >140 papers in Biology, Chemistry and Physics journals, including a range of highly cited publications in top journals, e.g., Science, Nature Medicine, Nature Methods, Nature Protocols, Nature Communications and Science Advances and have been funded from highly competitive sources.<\/span><\/p>\n

PURE profile<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

My group has made major discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer\u2019s disease (linking mitochondrial and synaptic dysfunction), where we have pioneered new models (including the first identification that cetaceans also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors (filed patents).<\/p>\n","protected":false},"author":71,"featured_media":211,"parent":0,"menu_order":0,"template":"","class_list":["post-210","research_group","type-research_group","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"group_members":"

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Dr Laura Aitken<\/div>\r\n
Dr Andrew Morton<\/div>\r\n
Doris Chen<\/div>\r\n
Pietro Esposito<\/div>\r\n
John Macintyre<\/div>\r\n
Stella Wigglesworth-Littlewood<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>","publications":"[publications flag='individual' code='fjg1' dois='1' max='10' categorise='1']","research_projects":"