{"id":218,"date":"2022-12-01T10:08:41","date_gmt":"2022-12-01T10:08:41","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&p=218"},"modified":"2022-12-21T10:18:16","modified_gmt":"2022-12-21T10:18:16","slug":"coote-group","status":"publish","type":"research_group","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-group\/coote-group\/","title":{"rendered":"Coote Group"},"content":{"rendered":"

Research is focused on identifying new treatments for Multi-Drug Resistant (MDR) human pathogens.<\/span>
\nNovel treatments can be single therapies or combinations. Combinations can be derived from antibiotics; antibiotic resistance ‘breakers’ eg. Beta-lactamase inhibitors; efflux-pump inhibitors; or repurposed drugs.<\/span>
\nPrincipal organisms tested are Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Fast-growing Mycobacteria and Candida albicans.<\/span>
\nIn addition to traditional in vitro microbiology techniques eg. MIC, checkerboard and time-kill assays we use an in vivo invertebrate infection model to test for efficacy of novel treatments versus real infections. This model employs the larvae of the Greater Wax moth (Galleria mellonella).<\/span><\/p>\n

Recent papers<\/span><\/p>\n

Carbapenem-only combination therapy against multi-drug resistant Pseudomonas aeruginosa: assessment of in vitro and in vivo efficacy and mode of action<\/span>
\nMackay, B., Parcell, B. J., Shirran, S. L. & Coote, P. J., 25 Oct 2022, In: Antibiotics. 11, 11, 19 p., 1467.<\/span><\/p>\n

Repurposing the anti-viral drug zidovudine (AZT) in combination with meropenem as an effective treatment for infections with multi-drug resistant, carbapenemase-producing strains of Klebsiella pneumoniae<\/span>
\nDeSarno, A. E., Parcell, B. J. & Coote, P. J., 14 Oct 2020, (E-pub ahead of print) In: Pathogens and Disease. Advance Article<\/span><\/p>\n

Dual \u03b2-lactam combination therapy for multi-drug resistant Pseudomonas aeruginosa infection: enhanced efficacy in vivo and comparison with monotherapies of penicillin-binding protein inhibition<\/span>
\nSiriyong, T., Murray, R. M., Bidgood, L. E., Young, S. A., Wright, F., Parcell, B. J., Voravuthikunchai, S. P. & Coote, P. J., 24 Jun 2019, In: Scientific Reports. 9, 13 p., 9098.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Research is focused on identifying new treatments for Multi-Drug Resistant (MDR) human pathogens.
\nNovel treatments can be single therapies or combinations. Combinations can be derived from antibiotics; antibiotic resistance ‘breakers’ eg. Beta-lactamase inhibitors; efflux-pump inhibitors; or repurposed drugs.<\/p>\n","protected":false},"author":66,"featured_media":219,"parent":0,"menu_order":0,"template":"","class_list":["post-218","research_group","type-research_group","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"group_members":"Peter Coote<\/span>","publications":"[publications flag='individual' code='pjc5' dois='1' max='10' categorise='1']","research_projects":"MSc (Res) projects are available :<\/span>\r\n\r\nhttps:\/\/www.st-andrews.ac.uk\/biology\/prospective\/pgr\/biomedical-sciences-mscres\/<\/span>","related_theme":[{"related_groups":[59,194,218,165,239],"related_centre":77,"ID":93,"post_title":"Infection and immunity","post_content":"BSRC infection biologists\u2019 study basic and applied aspects of viral, bacterial and parasite pathogens. Their research includes fundamental studies of pathogen replication and host interactions, antimicrobial resistance, therapeutic drug design and testing, and clinical and real-time diagnostics.<\/span>","post_excerpt":"BSRC infection biologists\u2019 study basic and applied aspects of viral, bacterial and parasite pathogens. Their research includes fundamental studies of pathogen replication and host interactions, antimicrobial resistance, therapeutic drug design and testing, and clinical and real-time diagnostics.","post_author":"4","post_date":"2022-01-18 01:47:43","post_date_gmt":"2022-01-18 01:47:43","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"infection-and-immunity","to_ping":"","pinged":"","post_modified":"2022-02-25 14:07:17","post_modified_gmt":"2022-02-25 14:07:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&p=93","menu_order":0,"post_type":"research_theme","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["137","4","2022-02-25 14:07:10","2022-02-25 14:07:10","","IMG_7497-Edit","","inherit","open","closed","","img_7497-edit","","","2022-02-25 14:07:10","2022-02-25 14:07:10","","93","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/01\/IMG_7497-Edit.jpg","0","attachment","image\/jpeg","0","137"],"id":93}],"related_centre":[{"ID":77,"post_title":"Biomedical Sciences Research Complex","post_content":"The\u00a0Biomedical Sciences Research Complex (BSRC) is an interdisciplinary centre for biomedical research with contributions from the Schools of Biology, Chemistry, Medicine, Physics and Astronomy.\u00a0The BSRC's main research themes are infection and immunity, biophysics, molecular medicine, and chemical biology.\u00a0<\/span>\r\n\r\nMain Website<\/a>","post_excerpt":"","post_author":"4","post_date":"2022-01-17 15:53:50","post_date_gmt":"2022-01-17 15:53:50","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biomedical-sciences-research-complex","to_ping":"","pinged":"","post_modified":"2022-09-20 13:31:47","post_modified_gmt":"2022-09-20 12:31:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_centre&p=77","menu_order":0,"post_type":"research_centre","post_mime_type":"","comment_count":"0","comments":false,"id":77}],"contact":"pjc5@st-andrews.ac.uk<\/span>","_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group\/218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/types\/research_group"}],"author":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/users\/66"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media\/219"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media?parent=218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}