{"id":263,"date":"2022-12-21T13:28:36","date_gmt":"2022-12-21T13:28:36","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&#038;p=263"},"modified":"2022-12-21T13:30:07","modified_gmt":"2022-12-21T13:30:07","slug":"alan-stewart-group-metal-ions-in-medicine","status":"publish","type":"research_group","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-group\/alan-stewart-group-metal-ions-in-medicine\/","title":{"rendered":"Alan Stewart Group &#8211; Metal ions in Medicine"},"content":{"rendered":"<p><span>Our work is centred on how metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling can lead to disease. A key part of my group\u2019s activity is the study of their interactions with circulatory proteins. At a cell and systems level, we are interested in how these interactions have a functional impact. We commonly utilise methods that examine the movement of Zn2+ and Ca2+ ions within cells and across membranes or measure their direct physiological functional outputs (e.g. coagulatory processes). Over the last few years, we have also worked closely with colleagues across the North Haugh particularly, the Mass Spectrometry Facility in St Andrews in the utilisation of quantitative proteomics clinical studies.<\/span><\/p>\n<p>Please visit our group website<span>: <a href=\"https:\/\/metalion.wp.st-andrews.ac.uk\/\">https:\/\/metalion.wp.st-andrews.ac.uk\/<\/a><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-264 size-full\" src=\"https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/12\/Picture1.png\" alt=\"\" width=\"1199\" height=\"494\" \/>Effects of fatty acid binding at the FA2 site on the primary zinc site of human serum albumin. (A) Structure of HSA with 5 molecules of myristate bound (PDB: 1BJ5). (B) Overlay of the main zinc-binding site in the myristate-bound structure (in green; PDB: 1BJ5) and the zinc-bound structure (in blue; PDB: 5IJF). A structural change is induced by fatty acid binding. This triggers the zinc-coordinating residue His67 to move 8 \u00c5 away from the other two coordinating side chains. Figure taken from Sobczak et al. (2021) <i>Chem. Sci. <\/i>12: 4079-4093.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our work is centred on how metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling can lead to disease.<\/p>\n","protected":false},"author":4,"featured_media":264,"parent":0,"menu_order":0,"template":"","class_list":["post-263","research_group","type-research_group","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"group_members":"<span>Dr Remi Fritzen; Research Fellow<\/span>\r\n<span>Dongmei Wu; PhD student<\/span>\r\n<span>Jordan Marsh; PhD student<\/span>\r\n<span>Stephen Hierons; PhD student<\/span>\r\n<span>Hasnain Ahmed; PhD student<\/span>\r\n<span>Amy Davies; Visiting Scholar<\/span>","publications":"[publications flag='individual' code='ajs21' dois='1' max='10' categorise='1']","research_projects":"<span>Bilateral BBSRC-FAPESP: A \"speciomic\" toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects.<\/span>\r\n\r\n<span>Tenovus Scotland: Assessment of the predictive value of plasma proteins in oesophageal adenocarcinoma treatment<\/span>\r\n\r\n<span>British Heart Foundation: Plasma non-esterified fatty acids and fibrin clot formation in obesity \u2013 a relationship forged in zinc?<\/span>\r\n\r\n<span>British Heart Foundation: Role of plasma fatty acid and zinc dynamics in platelet functioning: Implications for pathological clotting<\/span>","related_theme":[{"related_groups":[212,242,263],"related_centre":77,"ID":94,"post_title":"Biophysics","post_content":"<span>BSRC biophysicists study the fundamental molecular structures and interactions that underpin life. Their research spans the structure and molecular mechanism of enzyme function, the interactions between proteins in health and disease, and the mechanics of cell movement.<\/span>","post_excerpt":"BSRC biophysicists study the fundamental molecular structures and interactions that underpin life. ","post_author":"4","post_date":"2022-01-18 01:48:19","post_date_gmt":"2022-01-18 01:48:19","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biophysics","to_ping":"","pinged":"","post_modified":"2022-02-25 13:58:05","post_modified_gmt":"2022-02-25 13:58:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&#038;p=94","menu_order":0,"post_type":"research_theme","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["131","4","2022-02-25 13:57:54","2022-02-25 13:57:54","","MB-spreading-histoblast","","inherit","open","closed","","mb-spreading-histoblast","","","2022-02-25 13:57:54","2022-02-25 13:57:54","","94","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/01\/MB-spreading-histoblast.jpg","0","attachment","image\/jpeg","0","131"],"id":94},{"related_groups":[210,239,263],"related_centre":77,"ID":95,"post_title":"Molecular medicine","post_content":"BSRC researchers working in molecular medicine use interdisciplinary methods to study the fundamental molecular and mechanistic processes that underpin health, disease and ageing. Their research includes studies of heart disease, Alzheimer\u2019s, age related macular degeneration and handedness.","post_excerpt":"BSRC researchers working in molecular medicine use interdisciplinary methods to study the fundamental molecular and mechanistic processes that underpin health, disease and ageing. Their research includes studies of heart disease, Alzheimer\u2019s, age related macular degeneration and handedness.","post_author":"4","post_date":"2022-01-18 01:49:23","post_date_gmt":"2022-01-18 01:49:23","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"molecular-medicine","to_ping":"","pinged":"","post_modified":"2022-02-25 14:10:55","post_modified_gmt":"2022-02-25 14:10:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&#038;p=95","menu_order":0,"post_type":"research_theme","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["140","4","2022-02-25 14:10:49","2022-02-25 14:10:49","","IMG_7613-Edit","","inherit","open","closed","","img_7613-edit","","","2022-02-25 14:10:49","2022-02-25 14:10:49","","95","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/01\/IMG_7613-Edit.jpg","0","attachment","image\/jpeg","0","140"],"id":95},{"related_groups":[165,220,239,263],"related_centre":77,"ID":119,"post_title":"Chemical Biology","post_content":"Chemists working at the interface with biology or medicine in the BSRC study, synthesise and modify the small molecules that influence protein function. Using high-throughput techniques and the analysis of bioactive natural products, they develop compounds of medicinal value and gain insights into the mechanism of action of drug molecules.","post_excerpt":"Chemists working at the interface with biology or medicine in the BSRC study, synthesise and modify the small molecules that influence protein function. ","post_author":"4","post_date":"2022-01-21 09:40:59","post_date_gmt":"2022-01-21 09:40:59","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chemical-biology","to_ping":"","pinged":"","post_modified":"2022-02-25 14:01:22","post_modified_gmt":"2022-02-25 14:01:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&#038;p=119","menu_order":0,"post_type":"research_theme","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["132","4","2022-02-25 14:01:14","2022-02-25 14:01:14","","IMG_5041-1-scaled","","inherit","open","closed","","img_5041-1-scaled","","","2022-02-25 14:01:14","2022-02-25 14:01:14","","119","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/01\/IMG_5041-1-scaled-1.jpg","0","attachment","image\/jpeg","0","132"],"id":119},{"related_groups":[239,244,263],"related_centre":77,"ID":202,"post_title":"Human Diseases","post_content":"","post_excerpt":"","post_author":"4","post_date":"2022-11-28 11:02:56","post_date_gmt":"2022-11-28 11:02:56","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"human-diseases","to_ping":"","pinged":"","post_modified":"2022-11-28 14:30:40","post_modified_gmt":"2022-11-28 14:30:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&#038;p=202","menu_order":0,"post_type":"research_theme","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["207","4","2022-11-28 14:30:37","2022-11-28 14:30:37","","pexels-tima-miroshnichenko-6011611","","inherit","open","closed","","pexels-tima-miroshnichenko-6011611","","","2022-11-28 14:30:37","2022-11-28 14:30:37","","202","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/11\/pexels-tima-miroshnichenko-6011611.png","0","attachment","image\/png","0","207"],"id":202}],"related_centre":[{"ID":77,"post_title":"Biomedical Sciences Research Complex","post_content":"<span>The\u00a0Biomedical Sciences Research Complex (BSRC) is an interdisciplinary centre for biomedical research with contributions from the Schools of Biology, Chemistry, Medicine, Physics and Astronomy.\u00a0The BSRC's main research themes are infection and immunity, biophysics, molecular medicine, and chemical biology.\u00a0<\/span>\r\n\r\n<a href=\"https:\/\/biology.st-andrews.ac.uk\/bsrc\">Main Website<\/a>","post_excerpt":"","post_author":"4","post_date":"2022-01-17 15:53:50","post_date_gmt":"2022-01-17 15:53:50","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biomedical-sciences-research-complex","to_ping":"","pinged":"","post_modified":"2022-09-20 13:31:47","post_modified_gmt":"2022-09-20 12:31:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_centre&#038;p=77","menu_order":0,"post_type":"research_centre","post_mime_type":"","comment_count":"0","comments":false,"id":77}],"contact":"<span>Dr Alan J. Stewart PhD FRSB FRSC<\/span>\r\n<span>Reader in Molecular Medicine<\/span>\r\n<span>School of Medicine<\/span>\r\n<span>Medical and Biological Sciences Building<\/span>\r\n<span>University of St Andrews<\/span>\r\n<span>St Andrews<\/span>\r\n<span>Fife, KY16 9TF<\/span>\r\n<span>United Kingdom<\/span>\r\n\r\n<span>E-mail: ajs21@st-andrews.ac.uk<\/span>\r\n<span>Tel: +44 (0)1334 463546<\/span>","_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group\/263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_group"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/types\/research_group"}],"author":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/users\/4"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media\/264"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media?parent=263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}