{"id":95,"date":"2022-01-18T01:49:23","date_gmt":"2022-01-18T01:49:23","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_theme&#038;p=95"},"modified":"2022-02-25T14:10:55","modified_gmt":"2022-02-25T14:10:55","slug":"molecular-medicine","status":"publish","type":"research_theme","link":"https:\/\/biology.st-andrews.ac.uk\/research\/research-theme\/molecular-medicine\/","title":{"rendered":"Molecular medicine"},"content":{"rendered":"<p>BSRC researchers working in molecular medicine use interdisciplinary methods to study the fundamental molecular and mechanistic processes that underpin health, disease and ageing. Their research includes studies of heart disease, Alzheimer\u2019s, age related macular degeneration and handedness.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BSRC researchers working in molecular medicine use interdisciplinary methods to study the fundamental molecular and mechanistic processes that underpin health, disease and ageing. Their research includes studies of heart disease, Alzheimer\u2019s, age related macular degeneration and handedness.<\/p>\n","protected":false},"featured_media":140,"parent":0,"menu_order":0,"template":"","class_list":["post-95","research_theme","type-research_theme","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"related_groups":[{"group_members":"<div class=\"-IR-590\" aria-label=\"6. Group members Multi Line Text Required to answer \">\r\n<div class=\"-tH-620 \" data-automation-id=\"questionContent\">\r\n<div class=\"-yZ-223 \">\r\n<div class=\"-PN-237\">\r\n<div class=\"-xU-626\">Dr Laura Aitken<\/div>\r\n<div class=\"-xU-626\">Dr Andrew Morton<\/div>\r\n<div class=\"-xU-626\">Doris Chen<\/div>\r\n<div class=\"-xU-626\">Pietro Esposito<\/div>\r\n<div class=\"-xU-626\">John Macintyre<\/div>\r\n<div class=\"-xU-626\">Stella Wigglesworth-Littlewood<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>","publications":"[publications flag='individual' code='fjg1' dois='1' max='10' categorise='1']","research_projects":"<ul>\r\n \t<li><span>Inhibitors and activity of 17beta HSD10 in Alzheimer's disease<\/span><\/li>\r\n \t<li><span>Willin\/FRMD6 activity in Alzheimer's disease<\/span><\/li>\r\n \t<li><span>Non-human models of dementia<\/span><\/li>\r\n \t<li><span>Biophotonics<\/span><\/li>\r\n<\/ul>","related_theme":[95],"related_centre":77,"contact":"<span>fjg1@st-andrews.ac.uk<\/span>","ID":210,"post_title":"Gunn-Moore","post_content":"<span>My group has made major discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer\u2019s disease (linking mitochondrial and synaptic dysfunction), where we have pioneered new models (including the first identification that cetaceans also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors (filed patents). Using both molecular and novel biophysical techniques, we have also discovered novel biochemical pathways that are involved in the growth and development of mammalian neurons. These findings include the first identification of the protein FRMD6\/Willin as an upstream component of the Hippo pathway, which prior to our work, was thought to be involved only in cancer, but we have now linked its activity to Alzheimer\u2019s disease progression.<\/span>\r\n\r\n&nbsp;\r\n\r\n<span>I always claim that we are truly interdisciplinary, as we have published &gt;140 papers in Biology, Chemistry and Physics journals, including a range of highly cited publications in top journals, e.g., Science, Nature Medicine, Nature Methods, Nature Protocols, Nature Communications and Science Advances and have been funded from highly competitive sources.<\/span>\r\n\r\n<a href=\"https:\/\/risweb.st-andrews.ac.uk\/portal\/en\/persons\/frank-j-gunnmoore(b00c5dd1-3606-4696-9ce8-4504b04977bf).html\">PURE profile<\/a>","post_excerpt":"My group has made major discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer\u2019s disease (linking mitochondrial and synaptic dysfunction), where we have pioneered new models (including the first identification that cetaceans also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors (filed patents).","post_author":"71","post_date":"2022-11-28 15:55:52","post_date_gmt":"2022-11-28 15:55:52","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gunn-moore","to_ping":"","pinged":"","post_modified":"2022-12-21 10:20:37","post_modified_gmt":"2022-12-21 10:20:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&#038;p=210","menu_order":0,"post_type":"research_group","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["211","4","2022-11-28 15:55:17","2022-11-28 15:55:17","","20181114_SULSA_Gunn-Moore_004Col_Frank Gunn-Moore","Frank Gunn-Moore, SULSA Scottish Universities Life Sciences Alliance Executive Committee.","inherit","open","closed","","20181114_sulsa_gunn-moore_004col_frank-gunn-moore","","","2022-11-28 15:55:17","2022-11-28 15:55:17","","210","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/11\/20181114_SULSA_Gunn-Moore_004Col_Frank-Gunn-Moore.jpg","0","attachment","image\/jpeg","0","211"],"id":210},{"group_members":"<span>Dr Louise Major<\/span>\r\n<span>Dr Farhan Ali<\/span>\r\n<span>Dr Michela Cerone<\/span>\r\n\r\n<span>PhD students<\/span>\r\n<span>Jagwinder Dhaliwal<\/span>\r\n<span>William Mosedale<\/span>\r\n<span>Veronica Harris<\/span>\r\n<span>Rachel Humman<\/span>\r\n<span>Nora Von Xylander<\/span>\r\n<span>Berta Fatas<\/span>\r\n<span>Ngoc Anh Thu Trinh<\/span>\r\n<span>Vytautas Kuodis<\/span>\r\n<span>Peter Black<\/span>\r\n\r\n<span>M(Res)<\/span>\r\n<span>Oenone Bodman-Harris<\/span>","publications":"[publications flag='individual' code='tks1' dois='1' max='10' categorise='1']","research_projects":"<span>The Smith group uses their interfacial chemical\/biological expertise to find, validate and exploit differences between protozoan and mammalian metabolism.Smith is a leading international authority on parasite lipid metabolism with important publications in this area. His group have to date validated &gt;24 drug targets, conducted several screening campaigns and have 4 lead compound series, which are progressing through the drug discovery pipeline.<\/span>","related_theme":[202,200,119,95,93],"related_centre":77,"contact":"<span>Prof Terry K. Smith CChem, FRSC; FRSB<\/span>\r\n<span>Director of the Biomedical Sciences Research Complex<\/span>\r\n<span>University Biological Hazards Adviser<\/span>\r\n<span>Director of the Cat 3<\/span>\r\n<span>Radiation Safety Officer<\/span>\r\n<span>Office B3.10<\/span>\r\n<span>Biomedical Sciences Research Complex (BSRC),<\/span>\r\n<span>The North Haugh,<\/span>\r\n<span>The University,<\/span>\r\n<span>St. Andrews,<\/span>\r\n<span>Fife Scotland.<\/span>\r\n<span>KY16 9ST.<\/span>\r\n<span>Tel; office: 01334-463412<\/span>\r\n<span>Email: tks1@st-andrews.ac.uk<\/span>","ID":239,"post_title":"TKS","post_content":"<img class=\"aligncenter wp-image-241 size-full\" src=\"https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/12\/Slide1.jpg\" alt=\"\" width=\"1280\" height=\"720\" \/>\r\n\r\n&nbsp;\r\n\r\n<span>Prof Terry Smith is an expert in phospholipid metabolism and the use of mass spectrometry techniques and heads the Lipidomics Facility with GC-MSs and ABSciex 4000 QTrap for lipidomic and focussed metabolomics. Smith being a joint appointment between Biology and Chemistry also has access to a wide-range of world-class analytical facilities, some of which will be utilised in this proposal, i.e. GC-MS and NMR. Prof Smith has received funding from the Wellcome Trust, SULSA, EU and studentships from BBSRC and MRC. He has more than 27 years\u2019 experience in the molecular and biochemical parasitology arena, including T. brucei, T. cruzi, Leishmania, Toxoplasma and Plasmodium. He has published over 75 papers in the last 10 years, including numerous successful collaborations undertaking lipidomic analyses of various pathogens and numerous models for human diseases.<\/span>","post_excerpt":"Prof Terry Smith is an expert in phospholipid metabolism and the use of mass spectrometry techniques and heads the Lipidomics Facility with GC-MSs and ABSciex 4000 QTrap for lipidomic and focussed metabolomics.","post_author":"87","post_date":"2022-12-12 16:03:48","post_date_gmt":"2022-12-12 16:03:48","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tks","to_ping":"","pinged":"","post_modified":"2022-12-21 10:33:05","post_modified_gmt":"2022-12-21 10:33:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&#038;p=239","menu_order":0,"post_type":"research_group","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["241","4","2022-12-12 16:03:15","2022-12-12 16:03:15","","Terry Smith","","inherit","open","closed","","slide1","","","2022-12-12 16:03:25","2022-12-12 16:03:25","","239","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/12\/Slide1.jpg","0","attachment","image\/jpeg","0","241"],"id":239},{"group_members":"<span>Dr Remi Fritzen; Research Fellow<\/span>\r\n<span>Dongmei Wu; PhD student<\/span>\r\n<span>Jordan Marsh; PhD student<\/span>\r\n<span>Stephen Hierons; PhD student<\/span>\r\n<span>Hasnain Ahmed; PhD student<\/span>\r\n<span>Amy Davies; Visiting Scholar<\/span>","publications":"[publications flag='individual' code='ajs21' dois='1' max='10' categorise='1']","research_projects":"<span>Bilateral BBSRC-FAPESP: A \"speciomic\" toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects.<\/span>\r\n\r\n<span>Tenovus Scotland: Assessment of the predictive value of plasma proteins in oesophageal adenocarcinoma treatment<\/span>\r\n\r\n<span>British Heart Foundation: Plasma non-esterified fatty acids and fibrin clot formation in obesity \u2013 a relationship forged in zinc?<\/span>\r\n\r\n<span>British Heart Foundation: Role of plasma fatty acid and zinc dynamics in platelet functioning: Implications for pathological clotting<\/span>","related_theme":[94,95,119,202],"related_centre":77,"contact":"<span>Dr Alan J. Stewart PhD FRSB FRSC<\/span>\r\n<span>Reader in Molecular Medicine<\/span>\r\n<span>School of Medicine<\/span>\r\n<span>Medical and Biological Sciences Building<\/span>\r\n<span>University of St Andrews<\/span>\r\n<span>St Andrews<\/span>\r\n<span>Fife, KY16 9TF<\/span>\r\n<span>United Kingdom<\/span>\r\n\r\n<span>E-mail: ajs21@st-andrews.ac.uk<\/span>\r\n<span>Tel: +44 (0)1334 463546<\/span>","ID":263,"post_title":"Alan Stewart Group - Metal ions in Medicine","post_content":"<span>Our work is centred on how metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling can lead to disease. A key part of my group\u2019s activity is the study of their interactions with circulatory proteins. At a cell and systems level, we are interested in how these interactions have a functional impact. We commonly utilise methods that examine the movement of Zn2+ and Ca2+ ions within cells and across membranes or measure their direct physiological functional outputs (e.g. coagulatory processes). Over the last few years, we have also worked closely with colleagues across the North Haugh particularly, the Mass Spectrometry Facility in St Andrews in the utilisation of quantitative proteomics clinical studies.<\/span>\r\n\r\nPlease visit our group website<span>: <a href=\"https:\/\/metalion.wp.st-andrews.ac.uk\/\">https:\/\/metalion.wp.st-andrews.ac.uk\/<\/a><\/span>\r\n\r\n<img class=\"alignleft wp-image-264 size-full\" src=\"https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/12\/Picture1.png\" alt=\"\" width=\"1199\" height=\"494\" \/>Effects of fatty acid binding at the FA2 site on the primary zinc site of human serum albumin. (A) Structure of HSA with 5 molecules of myristate bound (PDB: 1BJ5). (B) Overlay of the main zinc-binding site in the myristate-bound structure (in green; PDB: 1BJ5) and the zinc-bound structure (in blue; PDB: 5IJF). A structural change is induced by fatty acid binding. This triggers the zinc-coordinating residue His67 to move 8 \u00c5 away from the other two coordinating side chains. Figure taken from Sobczak et al. (2021) <i>Chem. Sci. <\/i>12: 4079-4093.","post_excerpt":"Our work is centred on how metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling can lead to disease.","post_author":"4","post_date":"2022-12-21 13:28:36","post_date_gmt":"2022-12-21 13:28:36","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"alan-stewart-group-metal-ions-in-medicine","to_ping":"","pinged":"","post_modified":"2022-12-21 13:30:07","post_modified_gmt":"2022-12-21 13:30:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_group&#038;p=263","menu_order":0,"post_type":"research_group","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["264","4","2022-12-21 13:27:11","2022-12-21 13:27:11","","Picture1","","inherit","open","closed","","picture1","","","2022-12-21 13:27:11","2022-12-21 13:27:11","","263","https:\/\/biology.st-andrews.ac.uk\/research\/wp-content\/uploads\/sites\/17\/2022\/12\/Picture1.png","0","attachment","image\/png","0","264"],"id":263}],"related_centre":[{"ID":77,"post_title":"Biomedical Sciences Research Complex","post_content":"<span>The\u00a0Biomedical Sciences Research Complex (BSRC) is an interdisciplinary centre for biomedical research with contributions from the Schools of Biology, Chemistry, Medicine, Physics and Astronomy.\u00a0The BSRC's main research themes are infection and immunity, biophysics, molecular medicine, and chemical biology.\u00a0<\/span>\r\n\r\n<a href=\"https:\/\/biology.st-andrews.ac.uk\/bsrc\">Main Website<\/a>","post_excerpt":"","post_author":"4","post_date":"2022-01-17 15:53:50","post_date_gmt":"2022-01-17 15:53:50","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biomedical-sciences-research-complex","to_ping":"","pinged":"","post_modified":"2022-09-20 13:31:47","post_modified_gmt":"2022-09-20 12:31:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/research\/?post_type=research_centre&#038;p=77","menu_order":0,"post_type":"research_centre","post_mime_type":"","comment_count":"0","comments":false,"id":77}],"_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_theme\/95","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/research_theme"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/types\/research_theme"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media\/140"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/research\/wp-json\/wp\/v2\/media?parent=95"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}