{"id":1622,"date":"2022-01-20T22:17:40","date_gmt":"2022-01-20T22:17:40","guid":{"rendered":"https:\/\/biology.st-andrews.ac.uk\/students\/?post_type=module&#038;p=1622"},"modified":"2022-05-19T09:28:46","modified_gmt":"2022-05-19T08:28:46","slug":"bl3301-protein-structure-and-function","status":"publish","type":"module","link":"https:\/\/biology.st-andrews.ac.uk\/students\/module\/bl3301-protein-structure-and-function\/","title":{"rendered":"BL3301 &#8211; Protein structure and function"},"content":{"rendered":"<p><span>This module covers advanced aspects of protein science. The module introduces the major techniques for protein structure determination that are at the heart of biochemistry, molecular biology and drug discovery. The physical principles behind and strategies for elucidating protein structures by X-ray crystallography, NMR spectroscopy and cryo-electron microscopy are discussed. Membrane proteins are considered as an example of the impact of structural information on understanding biological function. The second part builds an understanding of thermodynamic and kinetic principles of protein interactions. Protein engineering by directed evolution will be introduced. This section is complemented by advanced aspects of enzyme kinetics and enzyme inhibition. The third part of the module considers protein folding and misfolding. It will be examined how proteins achieve functional three-dimensional structures. Protein misfolding diseases are used as examples to highlight the significance of protein folding. Prions and the molecular basis of spongiform encephalopathies are discussed in detail.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This module covers advanced aspects of protein science. The module introduces the major techniques for protein structure determination that are at the heart of biochemistry, molecular biology and drug discovery. The physical principles behind and strategies for elucidating protein structures by X-ray crystallography, NMR spectroscopy and cryo-electron microscopy are discussed. Membrane proteins are considered as&hellip;<\/p>\n","protected":false},"featured_media":1735,"parent":0,"menu_order":0,"template":"","format":"standard","skill":[],"class_list":["post-1622","module","type-module","status-publish","format-standard","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"assessment_details":"3-hour Written Examination = 50%, Coursework = 50%","contributing_staff":[{"user-id":"us6","role":"Senior Lecturer","module_organiser":1606,"phone":"","ID":1667,"post_title":"Dr Uli Schwarz-Linek","post_content":"","post_excerpt":"","post_author":"4","post_date":"2022-05-16 18:54:19","post_date_gmt":"2022-05-16 17:54:19","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dr-uli-schwarz-linek","to_ping":"","pinged":"","post_modified":"2022-05-18 11:50:49","post_modified_gmt":"2022-05-18 10:50:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/students\/?post_type=staff_member&#038;p=1667","menu_order":0,"post_type":"staff_member","post_mime_type":"","comment_count":"0","comments":false,"id":1667}],"learning_outcomes":"Students completing module BL3301 successfully should be able to:\r\n<ul>\r\n \t<li>Describe protein structure &amp; folding using a range of examples<\/li>\r\n \t<li>Relate protein structure to protein function<\/li>\r\n \t<li>Outline the methods used to characterise protein-ligand interactions<\/li>\r\n \t<li>Demonstrate the use of enzyme kinetics to characterise an enzyme<\/li>\r\n \t<li>Design experiments to explore enzyme activity<\/li>\r\n \t<li>Describe the methods used to explore protein structure<\/li>\r\n \t<li>Use in silico tools to characterise proteins, including biomolecular databases and molecular viewers<\/li>\r\n \t<li>Outline the methods used to characterise protein-ligand interactions<\/li>\r\n<\/ul>","module_code":"BL3301","programme":[{"related_modules":[1618,1621,1622,1623,1624,1626,1627,1628,1629,1631],"ID":1595,"post_title":"Animal Behaviour","post_content":"BSc(Hons)","post_excerpt":"","post_author":"4","post_date":"2022-01-20 21:33:21","post_date_gmt":"2022-01-20 21:33:21","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"animal-behaviour","to_ping":"","pinged":"","post_modified":"2022-01-20 22:28:50","post_modified_gmt":"2022-01-20 22:28:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/students\/?post_type=degree&#038;p=1595","menu_order":0,"post_type":"degree","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["400","10","2015-10-06 21:29:38","2015-10-06 21:29:38","","12036757_10153688467833787_4618725925346231596_n","","inherit","closed","closed","","12036757_10153688467833787_4618725925346231596_n","","","2015-10-06 21:29:38","2015-10-06 21:29:38","","0","https:\/\/biology.st-andrews.ac.uk\/students\/wp-content\/uploads\/sites\/6\/2015\/10\/12036757_10153688467833787_4618725925346231596_n.jpg","0","attachment","image\/jpeg","0","400"],"id":1595}],"skills":false,"timetable":"","module_code_year":"2021_2\/S1\/BL3301","credits":"20","semester":"1","module_organiser":false,"pre-requisite_modules":[{"assessment_details":"2-hour Written Examination = 50%, Coursework = 50%","contributing_staff":[1664,1807,1808,1792,1662,1669,1809],"learning_outcomes":"Students completing module BL2306 successfully should be able to:\r\n<ul>\r\n \t<li>Explain the chemistry and structure of the major biological macromolecules and how that determines their biological properties<\/li>\r\n \t<li>Mine, manipulate and interpret data from small molecule and macromolecular databases<\/li>\r\n \t<li>Use molecular viewers<\/li>\r\n \t<li>Explain the chemical and thermodynamic principles underlying biological catalysis and the role of enzymes and other proteins in determining the function and fate of cells and organisms<\/li>\r\n \t<li>Conduct experiments to explore enzyme activity<\/li>\r\n \t<li>Demonstrate a critical understanding of essential features of cell metabolism and its control, including topics such as energy and signal transduction, respiration and photosynthesis<\/li>\r\n \t<li>Appreciate the diversity of small molecules within cells, their dynamic concentration range and how to study these, both individually and as part of a metabolome<\/li>\r\n<\/ul>","module_code":"BL2306","programme":[1533],"skills":false,"timetable":"","module_code_year":"2021_2\/S2\/BL2306","credits":"15","semester":"2","module_organiser":1664,"pre-requisite_modules":[1606,1607],"additional_information":"Please check MMS regularly for additional module information","ID":1638,"post_title":"BL2306 - Biochemistry","post_content":"<span>Due to recent technological developments, metabolism and its regulation has re-emerged as an important area of Biology. This module will examine major biological macromolecules, the common motifs which occur in metabolic reactions, explore the properties of enzymes catalysing these reactions and consider the approaches to characterise the small molecule complement (metabolites) of biological systems. A number of central metabolic pathways and their control will be studied in detail, alongside examples of their importance in disease and recent metabolomic studies.<\/span>","post_excerpt":"","post_author":"4","post_date":"2022-01-20 22:35:13","post_date_gmt":"2022-01-20 22:35:13","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bl2306-biochemistry","to_ping":"","pinged":"","post_modified":"2022-06-28 12:58:12","post_modified_gmt":"2022-06-28 11:58:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/students\/?post_type=module&#038;p=1638","menu_order":0,"post_type":"module","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["1731","4","2022-05-18 16:37:41","2022-05-18 15:37:41","","BL2306","","inherit","open","closed","","bl2306","","","2022-05-18 16:37:41","2022-05-18 15:37:41","","0","https:\/\/biology.st-andrews.ac.uk\/students\/wp-content\/uploads\/sites\/6\/2022\/05\/BL2306.jpg","0","attachment","image\/jpeg","0","1731"],"post_format":false,"skill":false,"id":1638},{"assessment_details":"2-hour Written Examination = 50%, Coursework = 50%","contributing_staff":[1797],"learning_outcomes":"Students completing module BL2302 successfully should be able to:\r\n<ul>\r\n \t<li>Describe fundamental processes such as transcription, translation, DNA replication and repair.<\/li>\r\n \t<li>Develop an awareness of the genomics revolution and its impact on Biology.<\/li>\r\n \t<li>Develop practical skills in Molecular Biology.<\/li>\r\n \t<li>Develop skills required for Bioinformatic studies<\/li>\r\n<\/ul>","module_code":"BL2302","programme":[1533],"skills":false,"timetable":"","module_code_year":"2021_2\/S1\/BL2302","credits":"15","semester":"1","module_organiser":false,"pre-requisite_modules":[1606,1607],"additional_information":"","ID":1637,"post_title":"BL2302 - Molecular biology","post_content":"<span>Molecular biology is an essential tool within modern biology, widely used in biochemistry, cell biology and ecology. This module will provide an introduction to modern molecular biology. Lectures will cover fundamental biological processes such as transcription, translation, DNA replication and repair - as well as touch on the genomics revolution and how this has influenced the field. These concepts will be reinforced through laboratory practical classes where students will develop their practical skills and be exposed to the use of basic bioinformatics resources to analyse and interpret data.<\/span>","post_excerpt":"","post_author":"4","post_date":"2022-01-20 22:34:29","post_date_gmt":"2022-01-20 22:34:29","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bl2302-molecular-biology","to_ping":"","pinged":"","post_modified":"2022-05-18 16:55:48","post_modified_gmt":"2022-05-18 15:55:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/students\/?post_type=module&#038;p=1637","menu_order":0,"post_type":"module","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["1726","4","2022-05-18 16:37:28","2022-05-18 15:37:28","","BL2302","","inherit","open","closed","","bl2302","","","2022-05-18 16:37:28","2022-05-18 15:37:28","","0","https:\/\/biology.st-andrews.ac.uk\/students\/wp-content\/uploads\/sites\/6\/2022\/05\/BL2302.jpg","0","attachment","image\/jpeg","0","1726"],"post_format":false,"skill":false,"id":1637},{"assessment_details":"2-hour Written Examination = 50%, Coursework = 50%","contributing_staff":[1664],"learning_outcomes":"Students completing module BL2309 successfully should be able to:\r\n<ul>\r\n \t<li>Identify a range of key techniques that are commonly used in molecular biology.<\/li>\r\n \t<li>Describe the concepts behind key molecular biology techniques, which generally require the manipulation of DNA, RNA, protein or lipid.<\/li>\r\n \t<li>Discuss examples of how molecular biology techniques are used to address current questions and problems across a broad range of biological disciplines.<\/li>\r\n \t<li>Learn about the large scale omic approaches in biology with the integrated experimental design and data analysis<\/li>\r\n \t<li>Gain an understanding of molecular evolution and the application of comparative genomics<\/li>\r\n \t<li>Understand the molecular basis of evolution in ecology<\/li>\r\n \t<li>Describe the appplication of molecular tools to the detection, control and treatment of viral diseases<\/li>\r\n \t<li>Understand the molecular tools and techniques utilised in synthetic biology<\/li>\r\n \t<li>Be aware of the fundamental techniques used to genetically modify crops<\/li>\r\n<\/ul>","module_code":"BL2309","programme":false,"skills":false,"timetable":"","module_code_year":"2021_2\/S2\/BL2309","credits":"15","semester":"2","module_organiser":false,"pre-requisite_modules":[1606,1607],"additional_information":"","ID":1817,"post_title":"BL2309 - Applied Molecular Biology","post_content":"<span>Techniques in molecular biology represent a powerful box of tools that are used to address a wide variety of modern research questions across a broad range of biological disciplines including; ecology, biotechnology, cell biology, medicine, conservation biology, infectious disease, evolution, genetics and synthetic biology. Key molecular biology techniques will be introduced in the context of case studies that will provide examples of how molecular biology techniques are being used in cutting edge research to address real-life questions and problems that impact health, food security, the environment and the economy.<\/span>","post_excerpt":"","post_author":"4","post_date":"2022-05-19 09:11:19","post_date_gmt":"2022-05-19 08:11:19","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bl2309-applied-molecular-biology","to_ping":"","pinged":"","post_modified":"2022-05-19 09:11:19","post_modified_gmt":"2022-05-19 08:11:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/biology.st-andrews.ac.uk\/students\/?post_type=module&#038;p=1817","menu_order":0,"post_type":"module","post_mime_type":"","comment_count":"0","comments":false,"_thumbnail_id":["1732","4","2022-05-18 16:37:42","2022-05-18 15:37:42","image: Applied Molecular Biology - A Powerful Box of Tools\u2020","BL2309","image: Applied Molecular Biology - A Powerful Box of Tools","inherit","open","closed","","bl2309","","","2022-05-19 09:05:49","2022-05-19 08:05:49","","0","https:\/\/biology.st-andrews.ac.uk\/students\/wp-content\/uploads\/sites\/6\/2022\/05\/BL2309.jpg","0","attachment","image\/jpeg","0","1732"],"post_format":false,"skill":false,"id":1817}],"additional_information":"","_links":{"self":[{"href":"https:\/\/biology.st-andrews.ac.uk\/students\/wp-json\/wp\/v2\/module\/1622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.st-andrews.ac.uk\/students\/wp-json\/wp\/v2\/module"}],"about":[{"href":"https:\/\/biology.st-andrews.ac.uk\/students\/wp-json\/wp\/v2\/types\/module"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/students\/wp-json\/wp\/v2\/media\/1735"}],"wp:attachment":[{"href":"https:\/\/biology.st-andrews.ac.uk\/students\/wp-json\/wp\/v2\/media?parent=1622"}],"wp:term":[{"taxonomy":"skill","embeddable":true,"href":"https:\/\/biology.st-andrews.ac.uk\/students\/wp-json\/wp\/v2\/skill?post=1622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}