From Single-Molecules to Cells
From Single-molecules to Cells
Emma Verver, PhD, LUMICKS
1st July, 3.00pm, Microsoft Teams
A swiss army knife for high resolution study of
- DNA/RNA-Protein interaction
- Protein structure & Function
- Membrane and Cell mechanics
- Cellular signaling & Transport
Cellular processes are extremely dynamic and ensemble methods of studying these processes fall short in their ability to capture meaningful interactions over the timescales at which these systems operate. Single-molecule methods have proven to be powerful tools towards understanding key processes, such as DNA transcription, membrane dynamics and protein folding.
LUMICKS has developed novel biophysical tools to enable the unlocking of biological problems with simple, stand-alone solutions.
The C-Trap® is the world’s first instrument that integrates optical tweezers, confocal (STED) microscopy and an advanced microfluidics system in a truly correlated manner. The C-Trap® is capable of live, simultaneous and correlative visualization and manipulation of molecular interactions with sub-picoNewton force resolution and sub-nanometer position resolution. It can acquire information with a kilo-Hz (to mega-Hz) temporal resolution, such that even the fastest event can be captured. These abilities of the C-Trap® allow users to study a wide range of biological mechanisms from single molecules and their complex interactions to single-cell mechanics.
The presentation will show that the technological advances in hybrid single-molecule methods can be turned into an easy-to-use and stable instrument that can open new avenues in numerous research areas.